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  "id": "htan-wustl:HT480B1-S1H1Fs1U1Bp1",
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  "stratum": "brca-idc",
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  "site_source": "Primary",
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  "links": {
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  "id": "htan-wustl:HT480B1-S1H1Fs1U2Bp1",
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  "stratum": "brca-idc",
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  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Case treatment: None. Biospecimen tissue/timepoint: Primary; Baseline. The primary clinical table explicitly records no treatment for the collected case.",
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  "histology": "invasive ductal carcinoma / NST",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
  "he_mpp": null,
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  "links": {
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  "id": "htan-wustl:HT480B1-S1H3Fs1U1Bp1",
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  "cancer": "BRCA",
  "stratum": "brca-idc",
  "patient": "HT480B1",
  "capture": "HT480B1-S1H3Fs1U1Bp1",
  "accession": "HTA12_254_7",
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  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Case treatment: None. Biospecimen tissue/timepoint: Primary; Baseline. The primary clinical table explicitly records no treatment for the collected case.",
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  "histology": "invasive ductal carcinoma / NST",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
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 {
  "id": "htan-wustl:HT480B1-S1H3Fs1U2Bp1",
  "cohort": "htan-wustl",
  "cancer": "BRCA",
  "stratum": "brca-idc",
  "patient": "HT480B1",
  "capture": "HT480B1-S1H3Fs1U2Bp1",
  "accession": "HTA12_254_8",
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  "tier_reason": "Primary invasive carcinoma; original matched 20x H&E TIFF plus measured Visium counts, coordinates and scale factors are available from the source manifest.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Case treatment: None. Biospecimen tissue/timepoint: Primary; Baseline. The primary clinical table explicitly records no treatment for the collected case.",
  "diagnosis": "Ductal carcinoma NOS",
  "histology": "invasive ductal carcinoma / NST",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
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  "links": {
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 {
  "id": "htan-wustl:HT486B1-S1H1Fs1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "BRCA",
  "stratum": "brca-idc",
  "patient": "HT486B1",
  "capture": "HT486B1-S1H1Fs1U1Bp1",
  "accession": "HTA12_271_5",
  "tier": "core",
  "tier_reason": "Primary invasive carcinoma; original matched 20x H&E TIFF plus measured Visium counts, coordinates and scale factors are available from the source manifest.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Post-treatment",
  "treatment_note": "Case treatment: Cyclophosphamide, Methotrexate, Fluorouracil. Biospecimen tissue/timepoint: Primary; Baseline.",
  "diagnosis": "Ductal carcinoma NOS",
  "histology": "invasive ductal carcinoma / NST",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
  "he_mpp": null,
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  "links": {
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 {
  "id": "janesick-2023:GSM7782699",
  "cohort": "janesick-2023",
  "cancer": "BRCA",
  "stratum": "brca-idc",
  "patient": "Janesick_sample_1",
  "capture": "GSM7782699",
  "accession": "GSM7782699",
  "tier": "core",
  "tier_reason": "Original primary IDC biopsy is documented, with public original H&E TIFF, measured Visium counts and alignment package. One deposited Visium capture is counted, despite two replicates mentioned in methods.",
  "site": "Primary",
  "site_source": "primary breast biopsy, T2N1M0",
  "treatment": "Unknown",
  "treatment_note": "Primary IDC/DCIS biopsy is described, but primary status alone does not establish absence of prior treatment; inspected methods and GEO metadata do not report it.",
  "diagnosis": "primary invasive ductal breast carcinoma with associated DCIS",
  "histology": "invasive ductal carcinoma / NST",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original tissue-image TIFF and CytAssist image + spatial bundle available; validate Space Ranger transform before extracting archetype patches",
  "he_mpp": null,
  "he_mpp_basis": "Embedded (0.26) and crosswalk (0.55) values disagree; unresolved",
  "he_file": "GSM7782699_tissue_image.tif.gz",
  "links": {
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   "raw": [
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  },
  "expression_type": "filtered feature-barcode H5 gene counts; probe set and Space Ranger spatial bundle",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": "TNM: T2N1M0",
   "grade": null,
   "subsite": null,
   "markers": "ER: positive; PR: negative; HER2: positive"
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  "image_level": "original"
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 {
  "id": "htan-wustl:HT262B1-S1H2Fc2U1Z1Bs1",
  "cohort": "htan-wustl",
  "cancer": "BRCA",
  "stratum": "brca-ilc",
  "patient": "HT262B1",
  "capture": "HT262B1-S1H2Fc2U1Z1Bs1",
  "accession": "HTA12_246_3",
  "tier": "core",
  "tier_reason": "Primary invasive carcinoma; original matched 20x H&E TIFF plus measured Visium counts, coordinates and scale factors are available from the source manifest.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Case treatment: None. Biospecimen tissue/timepoint: Primary; Baseline. Other metadata caveat: Portal diagnosis/coding labels mixed lobular and ductal carcinoma 8522; Iglesia clinical supplement explicitly calls ILC with pT3 invasive lobular carcinoma and LCIS. Retained in ILC only, with conflict flag. The primary clinical table explicitly records no treatment for the collected case.",
  "diagnosis": "Lobular and ductal carcinoma",
  "histology": "invasive lobular carcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": "V10X_auxiliary_BRCA23/C1-HT262B1-S1H2Fc2U1.tif",
  "links": {
   "he": "https://www.synapse.org/Synapse:syn53215832",
   "expression": "https://www.synapse.org/Synapse:syn53215189",
   "coordinates": "https://www.synapse.org/Synapse:syn53215274",
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  "expression_type": "Space Ranger measured unfiltered UMI count matrix (MTX), barcodes/features; Level 4 Seurat RDS also available",
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 72",
   "sex": "Sex: Female",
   "stage": "Stage: IIA",
   "grade": "Grade: 2",
   "subsite": null,
   "markers": "HER2_IHC: 1+; PAM50_bulk: NA; PAM50_sn: NA; Clinical_Subtype: ER+"
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  "image_level": "original"
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 {
  "id": "htan-wustl:HT263B1-S1H1Fc2U1Z1Bs1",
  "cohort": "htan-wustl",
  "cancer": "BRCA",
  "stratum": "brca-ilc",
  "patient": "HT263B1",
  "capture": "HT263B1-S1H1Fc2U1Z1Bs1",
  "accession": "HTA12_139_3",
  "tier": "core",
  "tier_reason": "Primary invasive carcinoma; original matched 20x H&E TIFF plus measured Visium counts, coordinates and scale factors are available from the source manifest.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Case treatment: None. Biospecimen tissue/timepoint: Primary; Baseline. The primary clinical table explicitly records no treatment for the collected case.",
  "diagnosis": "Lobular carcinoma NOS",
  "histology": "invasive lobular carcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": "V10X_auxiliary_BRCA23/D1-HT263B1-S1H1Fc2U1.tif",
  "links": {
   "he": "https://www.synapse.org/Synapse:syn53215847",
   "expression": "https://www.synapse.org/Synapse:syn53215260",
   "coordinates": "https://www.synapse.org/Synapse:syn53215200",
   "raw": [
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  "expression_type": "Space Ranger measured unfiltered UMI count matrix (MTX), barcodes/features; Level 4 Seurat RDS also available",
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 68",
   "sex": "Sex: Female",
   "stage": "Stage: Unstaged",
   "grade": "Grade: 2",
   "subsite": null,
   "markers": "HER2_IHC: 0; PAM50_bulk: NA; PAM50_sn: LumB; Clinical_Subtype: ER+PR+"
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  "image_level": "original"
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 {
  "id": "htan-wustl:HT425B1-S1H2Fs1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "BRCA",
  "stratum": "brca-ilc",
  "patient": "HT425B1",
  "capture": "HT425B1-S1H2Fs1U1Bp1",
  "accession": "HTA12_266_5",
  "tier": "core",
  "tier_reason": "Primary invasive carcinoma; original matched 20x H&E TIFF plus measured Visium counts, coordinates and scale factors are available from the source manifest.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Case treatment: None. Biospecimen tissue/timepoint: Primary; Baseline. The primary clinical table explicitly records no treatment for the collected case.",
  "diagnosis": "Lobular carcinoma NOS",
  "histology": "invasive lobular carcinoma",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Identity matched by biospecimen ID. Validate/reconstruct full-resolution-to-capture transform using tissue_positions and scalefactors_json before patch extraction; not yet performed.",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": "V10X_auxiliary-spatial_clone/A1_HT425B1-S1H2Fs1U1.tif",
  "links": {
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   "raw": [
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  "expression_type": "Space Ranger measured unfiltered UMI count matrix (MTX), barcodes/features; Level 4 Seurat RDS also available",
  "access": {
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   "processed": "account",
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  "verified_on": "2026-10-09",
  "clinical": {
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   "sex": null,
   "stage": null,
   "grade": null,
   "subsite": null,
   "markers": null
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  "image_level": "original"
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 {
  "id": "htan-wustl:S16-38794-A3U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "COAD",
  "stratum": "coad-conv",
  "patient": "HTA12_280",
  "capture": "S16-38794-A3U1Bp1",
  "accession": "HTA12_280_3",
  "tier": "core",
  "tier_reason": "Publisher specimen A3 is colon/primary, intestinal adenocarcinoma (8140); paired E3 liver metastasis is a different section. Patient-level liver-biopsy metadata does not override section A3.",
  "site": "Primary",
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  "histology": "Adenocarcinoma intestinal type",
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  "accession": "GSM8594567",
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  "registration": "Alignment/scalefactors available; verify mapping before analysis",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
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  "registration": "Alignment/scalefactors available; verify mapping before analysis",
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  "he_file": null,
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   "processed": "account",
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  "verified_on": "2026-10-09",
  "clinical": {
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   "stage": null,
   "grade": null,
   "subsite": "organ_subsite: Not established at specimen level; see patient diagnostic site",
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 {
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  "cancer": "CRC",
  "stratum": null,
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  "capture": "HT253C1-Th1K1Fc2U1Z1Bs1",
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  "site": "Metastasis",
  "site_source": "Metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Published case treatment: FOLFOX + bevacizumab --> 5-FU/LV + bevacizumab --> FOLFOX + bev --> FOLFIRI + panitumumab --> irinotecan + panitumumab --> liver met resection and left colectomy (source of lab specimen) --> FOLFOX + bev. HTAN therapy: Yes; intent: Neoadjuvant; agents: Folfox. Published history places therapy before the resection supplying the laboratory specimen.",
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  "histology": "Adenocarcinoma metastatic NOS",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Alignment/scalefactors available; verify mapping before analysis",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
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  "capture": "HT260C1-Th1K1Fc2U1Z1Bs1",
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  "histology": "Adenocarcinoma metastatic NOS",
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  "preservation": "Fresh frozen",
  "linkage": "listed-together",
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  "he_file": null,
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  "histology": "Adenocarcinoma intestinal type",
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  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Alignment/scalefactors available; verify mapping before analysis",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
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 {
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  "site": "Metastasis",
  "site_source": "Metastasis",
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  "histology": "Adenocarcinoma intestinal type",
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  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Alignment/scalefactors available; verify mapping before analysis",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
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  "expression_type": "Measured Visium counts/processed matrices",
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   "age": "age_value: 21279; age_unit: days at diagnosis (source HTAN field)",
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  "id": "htan-wustl:HT165C1-Th1K3Fc2U1Z1Bs1",
  "cohort": "htan-wustl",
  "cancer": "CRC",
  "stratum": null,
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  "accession": "HTA12_258_6",
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  "site": "Metastasis",
  "site_source": "Metastasis",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: FOLIRINOX, XELIRI, XELIRI - complicated treatment history. HTAN therapy: yes; intent: Adjuvant; agents: mFOLFOX6. Treatment history is present or incomplete, but timing relative to the exact spatial specimen is unconfirmed.",
  "diagnosis": "Adenocarcinoma intestinal type",
  "histology": "Adenocarcinoma intestinal type",
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  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Alignment/scalefactors available; verify mapping before analysis",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
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  "id": "htan-wustl:HT213C1-Th1K4Fc2U1Z1Bs1",
  "cohort": "htan-wustl",
  "cancer": "CRC",
  "stratum": null,
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  "capture": "HT213C1-Th1K4Fc2U1Z1Bs1",
  "accession": "HTA12_259_5",
  "tier": "metastatic",
  "tier_reason": "Metastatic colorectal tumour section; useful only for a separate transfer analysis. Any unresolved carcinoma-NOS coding stays outside conventional core.",
  "site": "Metastasis",
  "site_source": "Metastasis",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: None. HTAN therapy: yes; intent: Neoadjuvant; agents: Capecitabine. Published None conflicts with the therapy record; collection-relative timing must be reconciled.",
  "diagnosis": "Adenocarcinoma intestinal type",
  "histology": "Adenocarcinoma intestinal type",
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  "preservation": "Fresh frozen",
  "linkage": "listed-together",
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  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
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  "cohort": "htan-wustl",
  "cancer": "CRC",
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  "diagnosis": "Adenocarcinoma intestinal type",
  "histology": "Adenocarcinoma intestinal type",
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  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Alignment/scalefactors available; verify mapping before analysis",
  "he_mpp": null,
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  "links": {
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  "expression_type": "Measured Visium counts/processed matrices",
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 {
  "id": "htan-wustl:HT413C1-Th1K2A1Us1_2Bp1",
  "cohort": "htan-wustl",
  "cancer": "CRC",
  "stratum": null,
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  "id": "htan-wustl:HT413C1-Th1K2A4U14Bp1",
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 {
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  "cohort": "htan-wustl",
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  "capture": "SN123_A551763_Rep1",
  "accession": null,
  "tier": "outside-stratum",
  "tier_reason": "Documented mucinous adenocarcinoma, excluded from conventional-adenocarcinoma core; Rep2 also low RNA quality.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Publisher patient table explicitly records Pre-treatment = No.",
  "diagnosis": "Adenocarcinoma, mucinous, moderately differentiated",
  "histology": "Adenocarcinoma, mucinous, moderately differentiated",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section-mapping-pending",
  "registration": "Pending capture-area crop/coordinate registration to physical-slide NDPI",
  "he_mpp": null,
  "he_mpp_basis": "40× NanoZoomer S360 per study methods; calibration not read",
  "he_file": "Visium%20Frozen_SN%20V19S23-123.ndpi",
  "links": {
   "he": "https://zenodo.org/records/7760264/files/Visium%20Frozen_SN%20V19S23-123.ndpi?download=1",
   "expression": "https://zenodo.org/records/7760264/files/SN123_A551763_Rep1.zip?download=1",
   "coordinates": "https://zenodo.org/records/7760264/files/SN123_A551763_Rep1.zip?download=1",
   "raw": []
  },
  "expression_type": "Measured Visium counts/processed matrices",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": null,
   "grade": "grade: See exact histological differentiation wording",
   "subsite": "organ_subsite: Cecum",
   "markers": "molecular_markers: BRAF V600E"
  },
  "image_level": "original"
 },
 {
  "id": "valdeolivas-2024:SN124_A551763_Rep2",
  "cohort": "valdeolivas-2024",
  "cancer": "COAD",
  "stratum": null,
  "patient": "A551763",
  "capture": "SN124_A551763_Rep2",
  "accession": null,
  "tier": "outside-stratum",
  "tier_reason": "Documented mucinous adenocarcinoma, excluded from conventional-adenocarcinoma core; Rep2 also low RNA quality.",
  "site": "Primary",
  "site_source": "Primary",
  "treatment": "Untreated",
  "treatment_note": "Publisher patient table explicitly records Pre-treatment = No.",
  "diagnosis": "Adenocarcinoma, mucinous, moderately differentiated",
  "histology": "Adenocarcinoma, mucinous, moderately differentiated",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section-mapping-pending",
  "registration": "Pending capture-area crop/coordinate registration to physical-slide NDPI",
  "he_mpp": null,
  "he_mpp_basis": "40× NanoZoomer S360 per study methods; calibration not read",
  "he_file": "Visium%20Frozen_SN%20V19S23-124.ndpi",
  "links": {
   "he": "https://zenodo.org/records/7760264/files/Visium%20Frozen_SN%20V19S23-124.ndpi?download=1",
   "expression": "https://zenodo.org/records/7760264/files/SN124_A551763_Rep2.zip?download=1",
   "coordinates": "https://zenodo.org/records/7760264/files/SN124_A551763_Rep2.zip?download=1",
   "raw": []
  },
  "expression_type": "Measured Visium counts/processed matrices",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": null,
   "grade": "grade: See exact histological differentiation wording",
   "subsite": "organ_subsite: Cecum",
   "markers": "molecular_markers: BRAF V600E"
  },
  "image_level": "original"
 },
 {
  "id": "zhang-2024-thca:P1",
  "cohort": "zhang-2024-thca",
  "cancer": "THCA",
  "stratum": "thca-ptc",
  "patient": "P1",
  "capture": "P1",
  "accession": "GSM7221915",
  "tier": "core",
  "tier_reason": "Primary PTC with matched original H&E at pathology resolution and measured Visium counts/coordinates. Keep PTC variant NOS and Hashimoto context explicit.",
  "site": "Primary",
  "site_source": "Primary thyroid-gland tumour; cohort pathology plus specimen source thyroid",
  "treatment": "Unknown",
  "treatment_note": "No pretreatment field in the four exact GEO records or original spatial-patient clinical Table S5. Primary thyroid sampling does not establish no earlier antitumour therapy. P3/P4 are human Hashimoto-only tissues, not Not applicable.",
  "diagnosis": "Papillary thyroid carcinoma with Hashimoto thyroiditis",
  "histology": "PTC variant not specified",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Coordinates supplied in original scan pixel space; coordinate bounds verified; overlay/pixel QC still required",
  "he_mpp": 0.469,
  "he_mpp_basis": "Estimated from spot spacing; header and coordinates inspected",
  "he_file": "GSM7221915_P1_HE.jpg.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7221nnn/GSM7221915/suppl/GSM7221915_P1_HE.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7221nnn/GSM7221915/suppl/GSM7221915_P1_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7221nnn/GSM7221915/suppl/GSM7221915_P1_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX20085048"
   ]
  },
  "expression_type": "Measured raw UMI count matrix (MTX), features and barcodes; public processed products",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "age_years: 56",
   "sex": "sex: female",
   "stage": null,
   "grade": null,
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "zhang-2024-thca:P2",
  "cohort": "zhang-2024-thca",
  "cancer": "THCA",
  "stratum": "thca-ptc",
  "patient": "P2",
  "capture": "P2",
  "accession": "GSM7221916",
  "tier": "core",
  "tier_reason": "Primary PTC with matched original H&E at pathology resolution and measured Visium counts/coordinates. Keep PTC variant NOS and Hashimoto context explicit.",
  "site": "Primary",
  "site_source": "Primary thyroid-gland tumour; cohort pathology plus specimen source thyroid",
  "treatment": "Unknown",
  "treatment_note": "No pretreatment field in the four exact GEO records or original spatial-patient clinical Table S5. Primary thyroid sampling does not establish no earlier antitumour therapy. P3/P4 are human Hashimoto-only tissues, not Not applicable.",
  "diagnosis": "Papillary thyroid carcinoma with Hashimoto thyroiditis",
  "histology": "PTC variant not specified",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Coordinates supplied in original scan pixel space; coordinate bounds verified; overlay/pixel QC still required",
  "he_mpp": 0.469,
  "he_mpp_basis": "Estimated from spot spacing; header and coordinates inspected",
  "he_file": "GSM7221916_P2_HE.jpg.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7221nnn/GSM7221916/suppl/GSM7221916_P2_HE.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7221nnn/GSM7221916/suppl/GSM7221916_P2_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7221nnn/GSM7221916/suppl/GSM7221916_P2_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX20085049"
   ]
  },
  "expression_type": "Measured raw UMI count matrix (MTX), features and barcodes; public processed products",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "age_years: 37",
   "sex": "sex: female",
   "stage": null,
   "grade": null,
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "gouin-2021:A1",
  "cohort": "gouin-2021",
  "cancer": "BLCA",
  "stratum": "blca-mibc",
  "patient": "Bladder1204",
  "capture": "A1",
  "accession": "GSM5224027",
  "tier": "core",
  "tier_reason": "Verified independent primary high-grade urothelial MIBC donor, original pathology-resolution JPEG and measured spatial counts/coordinates in matching original package.",
  "site": "Primary",
  "site_source": "Primary bladder tumour; spatial subset of untreated surgical MIBC cohort",
  "treatment": "Untreated",
  "treatment_note": "The exact four-patient Visium cohort is explicitly treatment-naive. Original paper describes surgery as the only treatment in the linked 25-patient MIBC cohort and no neoadjuvant chemotherapy.",
  "diagnosis": "Muscle-invasive bladder carcinoma",
  "histology": "High-grade urothelial carcinoma; detailed variant morphology unreported",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Pixel coordinates and scalefactors supplied; visual overlay QC pending",
  "he_mpp": 0.413,
  "he_mpp_basis": "Estimated from spot diameter; another estimate gives about 0.49",
  "he_file": "GSM5224027_A1.jpg.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM5224nnn/GSM5224027/suppl/GSM5224027_A1.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRP313147"
   ]
  },
  "expression_type": "Measured spot-level raw UMI counts in sparse H5AD X; 4,086 QC spots across 4 patients",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": "stage_stratum: MIBC",
   "grade": "grade: high",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "gouin-2021:D1",
  "cohort": "gouin-2021",
  "cancer": "BLCA",
  "stratum": "blca-mibc",
  "patient": "Bladder371",
  "capture": "D1",
  "accession": "GSM5224030",
  "tier": "core",
  "tier_reason": "Verified independent primary high-grade urothelial MIBC donor, original pathology-resolution JPEG and measured spatial counts/coordinates in matching original package.",
  "site": "Primary",
  "site_source": "Primary bladder tumour; spatial subset of untreated surgical MIBC cohort",
  "treatment": "Untreated",
  "treatment_note": "The exact four-patient Visium cohort is explicitly treatment-naive. Original paper describes surgery as the only treatment in the linked 25-patient MIBC cohort and no neoadjuvant chemotherapy.",
  "diagnosis": "Muscle-invasive bladder carcinoma",
  "histology": "High-grade urothelial carcinoma; detailed variant morphology unreported",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Pixel coordinates and scalefactors supplied; visual overlay QC pending",
  "he_mpp": 0.413,
  "he_mpp_basis": "Estimated from spot diameter; another estimate gives about 0.49",
  "he_file": "GSM5224030_D1.jpg.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM5224nnn/GSM5224030/suppl/GSM5224030_D1.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRP313147"
   ]
  },
  "expression_type": "Measured spot-level raw UMI counts in sparse H5AD X; 4,086 QC spots across 4 patients",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": "stage_stratum: MIBC",
   "grade": "grade: high",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "gouin-2021:C1",
  "cohort": "gouin-2021",
  "cancer": "BLCA",
  "stratum": "blca-mibc",
  "patient": "Bladder72",
  "capture": "C1",
  "accession": "GSM5224029",
  "tier": "core",
  "tier_reason": "Verified independent primary high-grade urothelial MIBC donor, original pathology-resolution JPEG and measured spatial counts/coordinates in matching original package.",
  "site": "Primary",
  "site_source": "Primary bladder tumour; spatial subset of untreated surgical MIBC cohort",
  "treatment": "Untreated",
  "treatment_note": "The exact four-patient Visium cohort is explicitly treatment-naive. Original paper describes surgery as the only treatment in the linked 25-patient MIBC cohort and no neoadjuvant chemotherapy.",
  "diagnosis": "Muscle-invasive bladder carcinoma",
  "histology": "High-grade urothelial carcinoma; detailed variant morphology unreported",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Pixel coordinates and scalefactors supplied; visual overlay QC pending",
  "he_mpp": 0.413,
  "he_mpp_basis": "Estimated from spot diameter; another estimate gives about 0.49",
  "he_file": "GSM5224029_C1.jpg.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM5224nnn/GSM5224029/suppl/GSM5224029_C1.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRP313147"
   ]
  },
  "expression_type": "Measured spot-level raw UMI counts in sparse H5AD X; 4,086 QC spots across 4 patients",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": "stage_stratum: MIBC",
   "grade": "grade: high",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "gouin-2021:B1",
  "cohort": "gouin-2021",
  "cancer": "BLCA",
  "stratum": "blca-mibc",
  "patient": "Bladder8",
  "capture": "B1",
  "accession": "GSM5224028",
  "tier": "core",
  "tier_reason": "Verified independent primary high-grade urothelial MIBC donor, original pathology-resolution JPEG and measured spatial counts/coordinates in matching original package.",
  "site": "Primary",
  "site_source": "Primary bladder tumour; spatial subset of untreated surgical MIBC cohort",
  "treatment": "Untreated",
  "treatment_note": "The exact four-patient Visium cohort is explicitly treatment-naive. Original paper describes surgery as the only treatment in the linked 25-patient MIBC cohort and no neoadjuvant chemotherapy.",
  "diagnosis": "Muscle-invasive bladder carcinoma",
  "histology": "High-grade urothelial carcinoma; detailed variant morphology unreported",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Pixel coordinates and scalefactors supplied; visual overlay QC pending",
  "he_mpp": 0.413,
  "he_mpp_basis": "Estimated from spot diameter; another estimate gives about 0.49",
  "he_file": "GSM5224028_B1.jpg.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM5224nnn/GSM5224028/suppl/GSM5224028_B1.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE171nnn/GSE171351/suppl/GSE171351_combined_visium.h5ad.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRP313147"
   ]
  },
  "expression_type": "Measured spot-level raw UMI counts in sparse H5AD X; 4,086 QC spots across 4 patients",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": "stage_stratum: MIBC",
   "grade": "grade: high",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "gse245908-lihc:CHC20",
  "cohort": "gse245908-lihc",
  "cancer": "LIHC",
  "stratum": "lihc-hcc",
  "patient": "CHC20",
  "capture": "CHC20",
  "accession": "GSM7850822",
  "tier": "core",
  "tier_reason": "Original same-section pathology-resolution image, measured counts and positions are public. Correct cross-GSM file mapping is explicit in original Info_Supp and dimension-consistent.",
  "site": "Primary",
  "site_source": "Primary tumour; liver resection",
  "treatment": "Untreated",
  "treatment_note": "GEO records treatment:none for this HCC specimen. No earlier anticancer therapy is indicated; this is sample-level metadata, not an independently reconstructed lifetime history.",
  "diagnosis": "Hepatocellular carcinoma",
  "histology": "HCC NOS; grade unknown",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Space Ranger coordinates/scalefactors and fiducial images provided. Identity confirmed; alignment not replayed/QC-tested. Original image is attached under other GSM.",
  "he_mpp": 0.454,
  "he_mpp_basis": "TIFF calibration; spot-based estimate differs (0.38)",
  "he_file": "GSM7850823_V10A20_026_CHC20-D1.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850823/suppl/GSM7850823_V10A20_026_CHC20-D1.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850822/suppl/GSM7850822_CHC20_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850822/suppl/GSM7850822_CHC20_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX22157661"
   ]
  },
  "expression_type": "Measured filtered feature-barcode HDF5 counts",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": null,
   "grade": null,
   "subsite": null,
   "markers": null
  },
  "image_level": "original",
  "field_sources": {
   "geometry_check": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850822/suppl/GSM7850822_CHC20_tissue_positions_list.csv.gz"
  },
  "geometry_check": {
   "finite_positions": true,
   "in_tissue_positions": 2261,
   "positions_outside_original": 0,
   "registration_signed_off": false
  }
 },
 {
  "id": "gse245908-lihc:CHC23",
  "cohort": "gse245908-lihc",
  "cancer": "LIHC",
  "stratum": "lihc-hcc",
  "patient": "CHC23",
  "capture": "CHC23",
  "accession": "GSM7850823",
  "tier": "core",
  "tier_reason": "Original same-section pathology-resolution image, measured counts and positions are public. Correct cross-GSM file mapping is explicit in original Info_Supp and dimension-consistent.",
  "site": "Primary",
  "site_source": "Primary tumour; liver resection",
  "treatment": "Untreated",
  "treatment_note": "GEO records treatment:none for this HCC specimen. No earlier anticancer therapy is indicated; this is sample-level metadata, not an independently reconstructed lifetime history.",
  "diagnosis": "Hepatocellular carcinoma",
  "histology": "HCC NOS; grade unknown",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Space Ranger coordinates/scalefactors and fiducial images provided. Identity confirmed; alignment not replayed/QC-tested. Original image is attached under other GSM.",
  "he_mpp": 0.454,
  "he_mpp_basis": "TIFF calibration; spot-based estimate differs (0.38)",
  "he_file": "GSM7850822_V10A20_025_CHC23-D1.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850822/suppl/GSM7850822_V10A20_025_CHC23-D1.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850823/suppl/GSM7850823_CHC23_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850823/suppl/GSM7850823_CHC23_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX22157662"
   ]
  },
  "expression_type": "Measured filtered feature-barcode HDF5 counts",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {
   "age": null,
   "sex": null,
   "stage": null,
   "grade": null,
   "subsite": null,
   "markers": null
  },
  "image_level": "original",
  "field_sources": {
   "geometry_check": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7850nnn/GSM7850823/suppl/GSM7850823_CHC23_tissue_positions_list.csv.gz"
  },
  "geometry_check": {
   "finite_positions": true,
   "in_tissue_positions": 1987,
   "positions_outside_original": 0,
   "registration_signed_off": false
  }
 },
 {
  "id": "steiner-2026:LM_SD_1216_8",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "11980",
  "capture": "LM_SD_1216_8",
  "accession": "GSM8427437",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Cribriform predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
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  "he_file": "V10N16-321_D1_flipped.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-321_D1_flipped.tif?download=1",
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   "processed": "open",
   "raw": "open"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-16",
  "clinical": {
   "age": "Age: 66",
   "sex": "Gender: M",
   "stage": "X8thStg: IB",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
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   "registration_signed_off": false
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 {
  "id": "steiner-2026:LM_SD_1216_12",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "13034",
  "capture": "LM_SD_1216_12",
  "accession": "GSM8427440",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Micropapillary predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-323_D1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-323_D1.tif?download=1",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427440/suppl/GSM8427440_LM_SD_1216_12_tissue_positions_list.csv.gz",
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
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   "processed": "open",
   "raw": "open"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 63",
   "sex": "Gender: F",
   "stage": "X8thStg: IIA",
   "grade": "WHO: 3",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
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 {
  "id": "steiner-2026:LM_SD_7",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "1984",
  "capture": "LM_SD_7",
  "accession": "GSM8427436",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Acinar predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": 0.5036,
  "he_mpp_basis": "Aperio header MPP read for this image; independent calibration QC pending",
  "he_file": "V10N16-321_C1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-321_C1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427436/suppl/GSM8427436_LM_SD_7_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427436/suppl/GSM8427436_LM_SD_7_tissue_positions_list.csv.gz",
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
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   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-16",
  "clinical": {
   "age": "Age: 52",
   "sex": "Gender: F",
   "stage": "X8thStg: IA1",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original",
  "field_sources": {
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   "he_mpp_basis": "https://zenodo.org/records/21842070/files/V10N16-321_C1.tif?download=1"
  }
 },
 {
  "id": "steiner-2026:LM_SD_11",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "21448",
  "capture": "LM_SD_11",
  "accession": "GSM8427430",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Cribriform predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": 0.5036,
  "he_mpp_basis": "Aperio header MPP read for this image; independent calibration QC pending",
  "he_file": "V10N16-323_C1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-323_C1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427430/suppl/GSM8427430_LM_SD_11_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427430/suppl/GSM8427430_LM_SD_11_tissue_positions_list.csv.gz",
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
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   "processed": "open",
   "raw": "open"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-16",
  "clinical": {
   "age": "Age: 68",
   "sex": "Gender: F",
   "stage": "X8thStg: IA3",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original",
  "field_sources": {
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   "he_mpp_basis": "https://zenodo.org/records/21842070/files/V10N16-323_C1.tif?download=1"
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 {
  "id": "steiner-2026:LM_SD_2",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "21448",
  "capture": "LM_SD_2",
  "accession": "GSM8427431",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Cribriform predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-322_B1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-322_B1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427431/suppl/GSM8427431_LM_SD_2_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427431/suppl/GSM8427431_LM_SD_2_tissue_positions_list.csv.gz",
   "raw": [
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 68",
   "sex": "Gender: F",
   "stage": "X8thStg: IA3",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
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 {
  "id": "steiner-2026:LM_SD_1216_14",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "22809",
  "capture": "LM_SD_1216_14",
  "accession": "GSM8427442",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Papillary predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-324_B1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-324_B1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427442/suppl/GSM8427442_LM_SD_1216_14_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427442/suppl/GSM8427442_LM_SD_1216_14_tissue_positions_list.csv.gz",
   "raw": [
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 72",
   "sex": "Gender: F",
   "stage": "X8thStg: IA1",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
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 {
  "id": "steiner-2026:LM_SD_15",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "25115",
  "capture": "LM_SD_15",
  "accession": "GSM8427443",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Lepidic predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-324_C1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-324_C1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427443/suppl/GSM8427443_LM_SD_15_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427443/suppl/GSM8427443_LM_SD_15_tissue_positions_list.csv.gz",
   "raw": [
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 75",
   "sex": "Gender: F",
   "stage": "X8thStg: IA2",
   "grade": "WHO: 1",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
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 {
  "id": "steiner-2026:LM_SD_3",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "27086",
  "capture": "LM_SD_3",
  "accession": "GSM8427432",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Acinar predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-322_C1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-322_C1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427432/suppl/GSM8427432_LM_SD_3_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427432/suppl/GSM8427432_LM_SD_3_tissue_positions_list.csv.gz",
   "raw": [
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 71",
   "sex": "Gender: M",
   "stage": "X8thStg: IA1",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
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 {
  "id": "steiner-2026:LM_SD_10",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "29063",
  "capture": "LM_SD_10",
  "accession": "GSM8427439",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Papillary predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-323_B1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-323_B1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427439/suppl/GSM8427439_LM_SD_10_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427439/suppl/GSM8427439_LM_SD_10_tissue_positions_list.csv.gz",
   "raw": [
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 69",
   "sex": "Gender: M",
   "stage": "X8thStg: IA2",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
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 {
  "id": "steiner-2026:LM_SD_1216_1",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "30868",
  "capture": "LM_SD_1216_1",
  "accession": "GSM8427428",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Acinar predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": 0.5036,
  "he_mpp_basis": "Aperio header MPP read for this image; independent calibration QC pending",
  "he_file": "V10N16-322_A1_flipped.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-322_A1_flipped.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427428/suppl/GSM8427428_LM_SD_1216_1_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427428/suppl/GSM8427428_LM_SD_1216_1_tissue_positions_list.csv.gz",
   "raw": [
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  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-16",
  "clinical": {
   "age": "Age: 68",
   "sex": "Gender: M",
   "stage": "X8thStg: IB",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original",
  "field_sources": {
   "he_mpp": "https://zenodo.org/records/21842070/files/V10N16-322_A1_flipped.tif?download=1",
   "he_mpp_basis": "https://zenodo.org/records/21842070/files/V10N16-322_A1_flipped.tif?download=1",
   "geometry_check": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427428/suppl/GSM8427428_LM_SD_1216_1_tissue_positions_list.csv.gz"
  },
  "geometry_check": {
   "finite_positions": true,
   "in_tissue_positions": 2401,
   "positions_outside_original": 0,
   "registration_signed_off": false
  }
 },
 {
  "id": "steiner-2026:LM_SD_16",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "30868",
  "capture": "LM_SD_16",
  "accession": "GSM8427429",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Acinar predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-324_D1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-324_D1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427429/suppl/GSM8427429_LM_SD_16_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427429/suppl/GSM8427429_LM_SD_16_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25507503"
   ]
  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 68",
   "sex": "Gender: M",
   "stage": "X8thStg: IB",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "steiner-2026:LM_SD_9",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "3255",
  "capture": "LM_SD_9",
  "accession": "GSM8427438",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Solid predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-323_A1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-323_A1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427438/suppl/GSM8427438_LM_SD_9_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427438/suppl/GSM8427438_LM_SD_9_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25507512"
   ]
  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 63",
   "sex": "Gender: F",
   "stage": "X8thStg: IA2",
   "grade": "WHO: 3",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "steiner-2026:LM_SD_4",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "4710",
  "capture": "LM_SD_4",
  "accession": "GSM8427433",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Solid predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-322_D1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-322_D1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427433/suppl/GSM8427433_LM_SD_4_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427433/suppl/GSM8427433_LM_SD_4_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25507507"
   ]
  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 66",
   "sex": "Gender: M",
   "stage": "X8thStg: IB",
   "grade": "WHO: 3",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "steiner-2026:LM_SD_5",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "611",
  "capture": "LM_SD_5",
  "accession": "GSM8427434",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Lepidic predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-321_A1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-321_A1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427434/suppl/GSM8427434_LM_SD_5_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427434/suppl/GSM8427434_LM_SD_5_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25507508"
   ]
  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 72",
   "sex": "Gender: M",
   "stage": "X8thStg: IA1",
   "grade": "WHO: 1",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "steiner-2026:LM_SD_13",
  "cohort": "steiner-2026",
  "cancer": "LUAD",
  "stratum": "luad-nonmuc",
  "patient": "915",
  "capture": "LM_SD_13",
  "accession": "GSM8427441",
  "tier": "core",
  "tier_reason": "Full measured same-section package, primary compatible histology, original pathology-resolution H&E, passes study QC.",
  "site": "Primary",
  "site_source": "Confirmed lung-primary surgical resection (cohort methods)",
  "treatment": "Untreated",
  "treatment_note": "Explicit no neoadjuvant or adjuvant anticancer therapy in the validation cohort. Applies also to LM_SD_6, which failed tissue-detachment QC and remains excluded for that reason.",
  "diagnosis": "Primary invasive non-mucinous lung adenocarcinoma",
  "histology": "Cribriform predominant",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "same-section",
  "registration": "Original supplied SpaceRanger image identity; verify coordinate transform/orientation. Author-provided flipped files retained. Scalefactors and spot pathology labels downloadable.",
  "he_mpp": null,
  "he_mpp_basis": "About 0.5 µm/pixel estimated for a representative capture (Aperio AT2); not read from each file",
  "he_file": "V10N16-324_A1.tif",
  "links": {
   "he": "https://zenodo.org/records/21842070/files/V10N16-324_A1.tif?download=1",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427441/suppl/GSM8427441_LM_SD_13_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8427nnn/GSM8427441/suppl/GSM8427441_LM_SD_13_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25507515"
   ]
  },
  "expression_type": "Measured spatial gene counts: matrix.mtx.gz plus features.tsv.gz/barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 65",
   "sex": "Gender: F",
   "stage": "X8thStg: IB",
   "grade": "WHO: 2",
   "subsite": null,
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5636",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvpos-nk",
  "patient": "P5636",
  "capture": "P5636",
  "accession": "GSM8283913",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283913_2022.05.30_Visium8A_P5636_20x.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283913/suppl/GSM8283913_2022.05.30_Visium8A_P5636_20x.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283913/suppl/GSM8283913_P5636_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283913/suppl/GSM8283913_P5636_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 46",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T2N1; Pathologic Stage: T2N1",
   "grade": "Grade: NA",
   "subsite": "Primary Site: Oropharynx; Tumor Subsite: Tonsil",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5692",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvpos-nk",
  "patient": "P5692",
  "capture": "P5692",
  "accession": "GSM8283909",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283909_2022.05.30_Visium8B_P5692_20x.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283909/suppl/GSM8283909_2022.05.30_Visium8B_P5692_20x.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283909/suppl/GSM8283909_P5692_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283909/suppl/GSM8283909_P5692_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 66",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T1N2; Pathologic Stage: T1N2",
   "grade": "Grade: NA",
   "subsite": "Primary Site: Oropharynx; Tumor Subsite: BOT",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5710",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvpos-nk",
  "patient": "P5710",
  "capture": "P5710",
  "accession": "GSM8283906",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283906_2021.07.22_Visium4B_P5710_20X_HE.ome.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283906/suppl/GSM8283906_2021.07.22_Visium4B_P5710_20X_HE.ome.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283906/suppl/GSM8283906_P5710_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283906/suppl/GSM8283906_P5710_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 64",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T1N2; Pathologic Stage: T2N1",
   "grade": "Grade: NA",
   "subsite": "Primary Site: Oropharynx; Tumor Subsite: Tonsil",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5735",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvpos-nk",
  "patient": "P5735",
  "capture": "P5735",
  "accession": "GSM8283905",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1. Documented second primary is separately flagged; prior surgery/chemoradiation, exclude from clean untreated first-primary subset.",
  "site": "Primary",
  "site_source": "second primary",
  "treatment": "Post-treatment",
  "treatment_note": "Prior to the sampled tissue, clinical table records Surgery/Chemoradiation. Documented second primary, with prior surgery/chemoradiation. Whether earlier therapy targeted this second primary or a prior cancer is not specified; retain prior exposure and second-primary flag.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283905_2021.07.22_Visium4C_P5735_20X_HE.ome.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283905/suppl/GSM8283905_2021.07.22_Visium4C_P5735_20X_HE.ome.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283905/suppl/GSM8283905_P5735_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283905/suppl/GSM8283905_P5735_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 66",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T2N1; Pathologic Stage: T2N1",
   "grade": "Grade: NA",
   "subsite": "Primary Site: Oropharynx; Tumor Subsite: BOT",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5764",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvpos-nk",
  "patient": "P5764",
  "capture": "P5764",
  "accession": "GSM8283901",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283901_2021.08.30_Vis6C_P5764_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283901/suppl/GSM8283901_2021.08.30_Vis6C_P5764_20X.tif.gz",
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   "sex": "Sex: M",
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   "grade": "Grade: NA",
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   "markers": null
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  "image_level": "original"
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 {
  "id": "simkin-2026:P5766",
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  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
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  "preservation": "Fresh frozen",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
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  "he_file": "GSM8283900_2021.08.30_Vis6D_P5766_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283900/suppl/GSM8283900_2021.08.30_Vis6D_P5766_20X.tif.gz",
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   "markers": null
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  "stratum": "hnsc-hpvpos-nk",
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  "site": "Primary",
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  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
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  "preservation": "Fresh frozen",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
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  "he_file": "GSM8283899_2021.10.04_Visium7D_P5767_HE_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283899/suppl/GSM8283899_2021.10.04_Visium7D_P5767_HE_20X.tif.gz",
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  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
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   "he": "open",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 51",
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   "grade": "Grade: NA",
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   "markers": null
  },
  "image_level": "original"
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  "id": "simkin-2026:P5903",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvpos-nk",
  "patient": "P5903",
  "capture": "P5903",
  "accession": "GSM8283898",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "nonkeratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283898_2022.05.30_Visium8C_P5903_20x.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283898/suppl/GSM8283898_2022.05.30_Visium8C_P5903_20x.tif.gz",
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  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
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   "grade": "Grade: NA",
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   "markers": null
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 {
  "id": "simkin-2026:P5418",
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  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5418",
  "capture": "P5418",
  "accession": "GSM8283919",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
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  "preservation": "Fresh frozen",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283919_2020.12.08.visium2.P5418.1a.HE.20x.ome.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283919/suppl/GSM8283919_2020.12.08.visium2.P5418.1a.HE.20x.ome.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283919/suppl/GSM8283919_P5418_matrix.mtx.gz",
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   "age": "Age: 70",
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   "markers": null
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  "image_level": "original"
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 {
  "id": "simkin-2026:P5456",
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  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
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  "capture": "P5456",
  "accession": "GSM8283917",
  "tier": "core",
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  "site": "Primary",
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  "diagnosis": "Head and neck squamous cell carcinoma",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
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  "he_file": "GSM8283917_2020.12.08.visium2.P5456.1b.HE.20x.ome.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283917/suppl/GSM8283917_2020.12.08.visium2.P5456.1b.HE.20x.ome.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283917/suppl/GSM8283917_P5456_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283917/suppl/GSM8283917_P5456_tissue_positions_list.csv.gz",
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   "grade": "Grade: G2",
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   "markers": null
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 {
  "id": "simkin-2026:P5612",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5612",
  "capture": "P5612",
  "accession": "GSM8283915",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
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  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
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  "preservation": "Fresh frozen",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283915_2021.10.04_Visium7A_P5612_HE_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283915/suppl/GSM8283915_2021.10.04_Visium7A_P5612_HE_20X.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283915/suppl/GSM8283915_P5612_matrix.mtx.gz",
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  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 40",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T2N3; Pathologic Stage: T2N2",
   "grade": "Grade: G2",
   "subsite": "Primary Site: Oral Cavity; Tumor Subsite: Tongue",
   "markers": null
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 {
  "id": "simkin-2026:P5624",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5624",
  "capture": "P5624",
  "accession": "GSM8283914",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
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  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
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  "preservation": "Fresh frozen",
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  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283914_2021.06.21_Visium3D_P5624_20X_HE.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283914/suppl/GSM8283914_2021.06.21_Visium3D_P5624_20X_HE.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283914/suppl/GSM8283914_P5624_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283914/suppl/GSM8283914_P5624_tissue_positions_list.csv.gz",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 39",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T4Nx; Pathologic Stage: T4aN3bM0",
   "grade": "Grade: G2",
   "subsite": "Primary Site: Larynx; Tumor Subsite: Supraglottis",
   "markers": null
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 {
  "id": "simkin-2026:P5659",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5659",
  "capture": "P5659",
  "accession": "GSM8283912",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
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  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
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  "he_mpp": 0.362,
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  "he_file": "GSM8283912_2021.08.30_Vis6A_P5659_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283912/suppl/GSM8283912_2021.08.30_Vis6A_P5659_20X.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283912/suppl/GSM8283912_P5659_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283912/suppl/GSM8283912_P5659_tissue_positions_list.csv.gz",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 77",
   "sex": "Sex: F",
   "stage": "Clinical Stage: T3N1; Pathologic Stage: T4aN3bM0",
   "grade": "Grade: G3",
   "subsite": "Primary Site: Oral Cavity; Tumor Subsite: Oral Tongue",
   "markers": null
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 {
  "id": "simkin-2026:P5684",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5684",
  "capture": "P5684",
  "accession": "GSM8283910",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
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  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
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  "he_mpp": 0.362,
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  "he_file": "GSM8283910_2021.06.21_Visium3B_P5684_20X_HE.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283910/suppl/GSM8283910_2021.06.21_Visium3B_P5684_20X_HE.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283910/suppl/GSM8283910_P5684_matrix.mtx.gz",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 65",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T3N2b; Pathologic Stage: T2N3b",
   "grade": "Grade: G2",
   "subsite": "Primary Site: Oral Cavity; Tumor Subsite: FOM",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5707",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5707",
  "capture": "P5707",
  "accession": "GSM8283908",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283908_2021.08.30_Vis6B_P5707_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283908/suppl/GSM8283908_2021.08.30_Vis6B_P5707_20X.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283908/suppl/GSM8283908_P5707_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283908/suppl/GSM8283908_P5707_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 64",
   "sex": "Sex: F",
   "stage": "Clinical Stage: T2N0; Pathologic Stage: T3N0M0",
   "grade": "Grade: G1/G2",
   "subsite": "Primary Site: Larynx; Tumor Subsite: Supraglottis",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5709",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5709",
  "capture": "P5709",
  "accession": "GSM8283907",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1. Prior radiation is flagged; exclude from clean untreated subset.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Post-treatment",
  "treatment_note": "Prior to the sampled tissue, clinical table records Radiation. Table still labels primary tissue; retain prior radiation explicitly rather than assume untreated first primary.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283907_2021.10.04_Visium7B_P5709_HE_20X_RGB.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283907/suppl/GSM8283907_2021.10.04_Visium7B_P5709_HE_20X_RGB.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283907/suppl/GSM8283907_P5709_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283907/suppl/GSM8283907_P5709_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 83",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T3N0; Pathologic Stage: T3N0",
   "grade": "Grade: G2",
   "subsite": "Primary Site: Larynx; Tumor Subsite: Glottis",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5736",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5736",
  "capture": "P5736",
  "accession": "GSM8283904",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.363,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283904_2021.08.25_Visium5A_P5736_1_20X_HE.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283904/suppl/GSM8283904_2021.08.25_Visium5A_P5736_1_20X_HE.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283904/suppl/GSM8283904_P5736_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283904/suppl/GSM8283904_P5736_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 66",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T4aN0; Pathologic Stage: T4aN0M0",
   "grade": "Grade: G2",
   "subsite": "Primary Site: Larynx; Tumor Subsite: Supraglottis",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5751",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5751",
  "capture": "P5751",
  "accession": "GSM8283903",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283903_2021.08.25_Visium5D_P5751_20X_HE.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283903/suppl/GSM8283903_2021.08.25_Visium5D_P5751_20X_HE.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283903/suppl/GSM8283903_P5751_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283903/suppl/GSM8283903_P5751_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 64",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T3N2b; Pathologic Stage: T3N0M0",
   "grade": "Grade: G3",
   "subsite": "Primary Site: Oropharynx; Tumor Subsite: BOT",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5756",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5756",
  "capture": "P5756",
  "accession": "GSM8283902",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283902_2021.10.04_Visium7C_P5756_HE_20X.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283902/suppl/GSM8283902_2021.10.04_Visium7C_P5756_HE_20X.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283902/suppl/GSM8283902_P5756_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283902/suppl/GSM8283902_P5756_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 60",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T4aN3b; Pathologic Stage: T4aN3b",
   "grade": "Grade: G2/G3",
   "subsite": "Primary Site: Oropharynx; Tumor Subsite: BOT",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "simkin-2026:P5909",
  "cohort": "simkin-2026",
  "cancer": "HNSC",
  "stratum": "hnsc-hpvneg-k",
  "patient": "P5909",
  "capture": "P5909",
  "accession": "GSM8283897",
  "tier": "core",
  "tier_reason": "Primary conventional mucosal SCC with public measured spatial counts, full-resolution coordinates and separate original H&E TIFF; clinical subtype/site/HPV verified in Supplementary Table 1.",
  "site": "Primary",
  "site_source": "first primary",
  "treatment": "Unknown",
  "treatment_note": "Prior Tx Type is NA, without an NA definition or explicit treatment-naive inclusion rule. Unknown, not confirmed Untreated. Subsequent adjuvant therapy does not establish treatment before sampling.",
  "diagnosis": "Head and neck squamous cell carcinoma",
  "histology": "keratinizing SCC",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Full-resolution tissue_positions + scalefactors supplied. No separate serial-section registration; routine alignment QC needed.",
  "he_mpp": 0.362,
  "he_mpp_basis": "Estimated from Visium spot diameter; TIFF calibration tag not read",
  "he_file": "GSM8283897_2022.05.30_Visium8D_P5909_20x.tif.gz",
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283897/suppl/GSM8283897_2022.05.30_Visium8D_P5909_20x.tif.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283897/suppl/GSM8283897_P5909_matrix.mtx.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8283nnn/GSM8283897/suppl/GSM8283897_P5909_tissue_positions_list.csv.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1114040"
   ]
  },
  "expression_type": "Measured UMI counts: matrix.mtx.gz + features.tsv.gz + barcodes.tsv.gz",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "Age: 62",
   "sex": "Sex: M",
   "stage": "Clinical Stage: T4N2c; Pathologic Stage: T3N3b",
   "grade": "Grade: G2",
   "subsite": "Primary Site: Oral Cavity; Tumor Subsite: Oral Tongue",
   "markers": null
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452847",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt1",
  "capture": "GSM8452847",
  "accession": "GSM8452847",
  "source_name": "Pt-1A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452847/suppl/GSM8452847_Pt-1_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452847/suppl/GSM8452847_Pt-1A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452847/suppl/GSM8452847_Pt-1A_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681325"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "83 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452848",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt1",
  "capture": "GSM8452848",
  "accession": "GSM8452848",
  "source_name": "Pt-1B",
  "tier": "held",
  "tier_reason": "Pt-1B liver metastasis has median 130 UMIs and 93 genes per spot. Hold principal expression validation pending tumour-region QC; donor retained through other sections.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452848/suppl/GSM8452848_Pt-1_B.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452848/suppl/GSM8452848_Pt-1B_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452848/suppl/GSM8452848_Pt-1B_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681326"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "83 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452849",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt1",
  "capture": "GSM8452849",
  "accession": "GSM8452849",
  "source_name": "Pt-1C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452849/suppl/GSM8452849_Pt-1_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452849/suppl/GSM8452849_Pt-1C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452849/suppl/GSM8452849_Pt-1C_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681327"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "83 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452850",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt2",
  "capture": "GSM8452850",
  "accession": "GSM8452850",
  "source_name": "Pt-2A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452850/suppl/GSM8452850_Pt-2_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452850/suppl/GSM8452850_Pt-2A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452850/suppl/GSM8452850_Pt-2A_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681328"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "79 years (Table S1)",
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   "grade": "Not reported",
   "subsite": null,
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 {
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  "stratum": "pdac-conv",
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  "accession": "GSM8452851",
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  "site_source": "Lung metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
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  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
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 {
  "id": "pei-2025:GSM8452852",
  "cohort": "pei-2025",
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  "stratum": "pdac-conv",
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  "accession": "GSM8452852",
  "source_name": "Pt-2C",
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  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
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  "site_source": "Peritoneal metastasis",
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  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
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   "sex": "F",
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 {
  "id": "pei-2025:GSM8452853",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
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  "capture": "GSM8452853",
  "accession": "GSM8452853",
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  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "89 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452854",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt3",
  "capture": "GSM8452854",
  "accession": "GSM8452854",
  "source_name": "Pt-3B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
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  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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  "verified_on": "2026-10-09",
  "clinical": {
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   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452855",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt3",
  "capture": "GSM8452855",
  "accession": "GSM8452855",
  "source_name": "Pt-3C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Untreated",
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  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
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   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452856",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt4",
  "capture": "GSM8452856",
  "accession": "GSM8452856",
  "source_name": "Pt-4A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
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   "subsite": null,
   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452857",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt4",
  "capture": "GSM8452857",
  "accession": "GSM8452857",
  "source_name": "Pt-4B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
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  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
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   "subsite": null,
   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452858",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt4",
  "capture": "GSM8452858",
  "accession": "GSM8452858",
  "source_name": "Pt-4C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Lung metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
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  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
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   "markers": "Not reported"
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 {
  "id": "pei-2025:GSM8452859",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt4",
  "capture": "GSM8452859",
  "accession": "GSM8452859",
  "source_name": "Pt-4D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
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  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
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  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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  "verified_on": "2026-10-09",
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   "age": "79 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452860",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt5",
  "capture": "GSM8452860",
  "accession": "GSM8452860",
  "source_name": "Pt-5A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
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  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "84 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452861",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt5",
  "capture": "GSM8452861",
  "accession": "GSM8452861",
  "source_name": "Pt-5B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "raw": "open"
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  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "84 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452862",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt5",
  "capture": "GSM8452862",
  "accession": "GSM8452862",
  "source_name": "Pt-5C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452862/suppl/GSM8452862_Pt-5_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452862/suppl/GSM8452862_Pt-5C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452862/suppl/GSM8452862_Pt-5C_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "84 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452863",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt6",
  "capture": "GSM8452863",
  "accession": "GSM8452863",
  "source_name": "Pt-6A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, AVN944, erlotinib. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452863/suppl/GSM8452863_Pt-6_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452863/suppl/GSM8452863_Pt-6A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452863/suppl/GSM8452863_Pt-6A_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
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  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452864",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt6",
  "capture": "GSM8452864",
  "accession": "GSM8452864",
  "source_name": "Pt-6B",
  "tier": "held",
  "tier_reason": "Pt-6B liver metastasis has 185 neoplastic / 2669 passing spots (6.93%). Review malignant-region coverage before using for tumour-state validation.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, AVN944, erlotinib. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452864/suppl/GSM8452864_Pt-6_B.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452864/suppl/GSM8452864_Pt-6B_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452864/suppl/GSM8452864_Pt-6B_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681342"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452865",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt6",
  "capture": "GSM8452865",
  "accession": "GSM8452865",
  "source_name": "Pt-6C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, AVN944, erlotinib. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452865/suppl/GSM8452865_Pt-6_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452865/suppl/GSM8452865_Pt-6C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452865/suppl/GSM8452865_Pt-6C_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681343"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452866",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt6",
  "capture": "GSM8452866",
  "accession": "GSM8452866",
  "source_name": "Pt-6D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, AVN944, erlotinib. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452866/suppl/GSM8452866_Pt-6_D.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452866/suppl/GSM8452866_Pt-6D_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452866/suppl/GSM8452866_Pt-6D_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681344"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452867",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt7",
  "capture": "GSM8452867",
  "accession": "GSM8452867",
  "source_name": "Pt-7A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, ADH1, cisplatin. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452867/suppl/GSM8452867_Pt-7_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452867/suppl/GSM8452867_Pt-7A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452867/suppl/GSM8452867_Pt-7A_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "57 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452868",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt7",
  "capture": "GSM8452868",
  "accession": "GSM8452868",
  "source_name": "Pt-7B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, ADH1, cisplatin. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452868/suppl/GSM8452868_Pt-7_B.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452868/suppl/GSM8452868_Pt-7B_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452868/suppl/GSM8452868_Pt-7B_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "57 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452869",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt7",
  "capture": "GSM8452869",
  "accession": "GSM8452869",
  "source_name": "Pt-7C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, ADH1, cisplatin. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452869/suppl/GSM8452869_Pt-7_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452869/suppl/GSM8452869_Pt-7C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452869/suppl/GSM8452869_Pt-7C_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "57 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452870",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt7",
  "capture": "GSM8452870",
  "accession": "GSM8452870",
  "source_name": "Pt-7D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, ADH1, cisplatin. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452870/suppl/GSM8452870_Pt-7_D.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452870/suppl/GSM8452870_Pt-7D_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452870/suppl/GSM8452870_Pt-7D_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "57 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452871",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt8",
  "capture": "GSM8452871",
  "accession": "GSM8452871",
  "source_name": "Pt-8A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, FOLFIRI, Abraxane/Gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452871/suppl/GSM8452871_Pt-8_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452871/suppl/GSM8452871_Pt-8A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452871/suppl/GSM8452871_Pt-8A_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681349"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "67 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452872",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt8",
  "capture": "GSM8452872",
  "accession": "GSM8452872",
  "source_name": "Pt-8B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, FOLFIRI, Abraxane/Gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452872/suppl/GSM8452872_Pt-8_B.jpg.gz",
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 {
  "id": "pei-2025:GSM8452873",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt8",
  "capture": "GSM8452873",
  "accession": "GSM8452873",
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  "site": "Metastasis",
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  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, FOLFIRI, Abraxane/Gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "sex": "M",
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 {
  "id": "pei-2025:GSM8452874",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt8",
  "capture": "GSM8452874",
  "accession": "GSM8452874",
  "source_name": "Pt-8D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, FOLFIRI, Abraxane/Gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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  "verified_on": "2026-10-09",
  "clinical": {
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   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
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  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452875",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt9",
  "capture": "GSM8452875",
  "accession": "GSM8452875",
  "source_name": "Pt-9A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: Cisplatin, gemcitabine, ADH-1, 5-FU (Clinical trial). Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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  "expression_type": null,
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  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452876",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt9",
  "capture": "GSM8452876",
  "accession": "GSM8452876",
  "source_name": "Pt-9B",
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  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: Cisplatin, gemcitabine, ADH-1, 5-FU (Clinical trial). Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452876/suppl/GSM8452876_Pt-9B_spatial.tar.gz",
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  "expression_type": null,
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  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452877",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt9",
  "capture": "GSM8452877",
  "accession": "GSM8452877",
  "source_name": "Pt-9C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: Cisplatin, gemcitabine, ADH-1, 5-FU (Clinical trial). Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452877/suppl/GSM8452877_Pt-9C_spatial.tar.gz",
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  "verified_on": "2026-10-09",
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   "age": "60 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452878",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt9",
  "capture": "GSM8452878",
  "accession": "GSM8452878",
  "source_name": "Pt-9D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
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  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452878/suppl/GSM8452878_Pt-9D_spatial.tar.gz",
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  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452879",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt10",
  "capture": "GSM8452879",
  "accession": "GSM8452879",
  "source_name": "Pt-10A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, carboplatin/FOLFOX, gemcitabine/abraxane. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452879/suppl/GSM8452879_Pt-10_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452879/suppl/GSM8452879_Pt-10A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452879/suppl/GSM8452879_Pt-10A_spatial.tar.gz",
   "raw": [
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  "expression_type": null,
  "access": {
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  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "64 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452880",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt10",
  "capture": "GSM8452880",
  "accession": "GSM8452880",
  "source_name": "Pt-10B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, carboplatin/FOLFOX, gemcitabine/abraxane. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452880/suppl/GSM8452880_Pt-10_B.jpg.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452880/suppl/GSM8452880_Pt-10B_spatial.tar.gz",
   "raw": [
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  "access": {
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  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "64 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452881",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt10",
  "capture": "GSM8452881",
  "accession": "GSM8452881",
  "source_name": "Pt-10C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Lung metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, carboplatin/FOLFOX, gemcitabine/abraxane. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452881/suppl/GSM8452881_Pt-10_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452881/suppl/GSM8452881_Pt-10C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452881/suppl/GSM8452881_Pt-10C_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
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   "raw": "open"
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  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "64 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452882",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt10",
  "capture": "GSM8452882",
  "accession": "GSM8452882",
  "source_name": "Pt-10D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, carboplatin/FOLFOX, gemcitabine/abraxane. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452882/suppl/GSM8452882_Pt-10_D.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452882/suppl/GSM8452882_Pt-10D_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452882/suppl/GSM8452882_Pt-10D_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
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   "raw": "open"
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  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "64 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452883",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt11",
  "capture": "GSM8452883",
  "accession": "GSM8452883",
  "source_name": "Pt-11A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, Oxaliplatin, leucovorin-modulated 5-FU, irinotecan,. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452883/suppl/GSM8452883_Pt-11_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452883/suppl/GSM8452883_Pt-11A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452883/suppl/GSM8452883_Pt-11A_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681361"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "67 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452884",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt11",
  "capture": "GSM8452884",
  "accession": "GSM8452884",
  "source_name": "Pt-11B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, Oxaliplatin, leucovorin-modulated 5-FU, irinotecan,. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452884/suppl/GSM8452884_Pt-11_B.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452884/suppl/GSM8452884_Pt-11B_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452884/suppl/GSM8452884_Pt-11B_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681362"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "67 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452885",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt11",
  "capture": "GSM8452885",
  "accession": "GSM8452885",
  "source_name": "Pt-11C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Lung metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, Oxaliplatin, leucovorin-modulated 5-FU, irinotecan,. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452885/suppl/GSM8452885_Pt-11_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452885/suppl/GSM8452885_Pt-11C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452885/suppl/GSM8452885_Pt-11C_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681363"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "67 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452886",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt11",
  "capture": "GSM8452886",
  "accession": "GSM8452886",
  "source_name": "Pt-11D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, Oxaliplatin, leucovorin-modulated 5-FU, irinotecan,. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452886/suppl/GSM8452886_Pt-11_D.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452886/suppl/GSM8452886_Pt-11D_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452886/suppl/GSM8452886_Pt-11D_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681364"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "67 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IIB; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452887",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt12",
  "capture": "GSM8452887",
  "accession": "GSM8452887",
  "source_name": "Pt-12A",
  "tier": "held",
  "tier_reason": "Pt-12A primary has 17 neoplastic / 2852 passing spots (0.596%). Hold from principal malignant-archetype validation pending region-level pathology and RNA QC; donor retained through other sections.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452887/suppl/GSM8452887_Pt-12_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452887/suppl/GSM8452887_Pt-12A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452887/suppl/GSM8452887_Pt-12A_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "78 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452888",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt12",
  "capture": "GSM8452888",
  "accession": "GSM8452888",
  "source_name": "Pt-12B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452888/suppl/GSM8452888_Pt-12_B.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452888/suppl/GSM8452888_Pt-12B_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452888/suppl/GSM8452888_Pt-12B_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "78 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452889",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt12",
  "capture": "GSM8452889",
  "accession": "GSM8452889",
  "source_name": "Pt-12C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Lung metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452889/suppl/GSM8452889_Pt-12_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452889/suppl/GSM8452889_Pt-12C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452889/suppl/GSM8452889_Pt-12C_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681367"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "78 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452890",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt12",
  "capture": "GSM8452890",
  "accession": "GSM8452890",
  "source_name": "Pt-12D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452890/suppl/GSM8452890_Pt-12_D.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452890/suppl/GSM8452890_Pt-12D_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452890/suppl/GSM8452890_Pt-12D_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681368"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "78 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452891",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8452891",
  "accession": "GSM8452891",
  "source_name": "Pt-13A",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452891/suppl/GSM8452891_Pt-13_A.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452891/suppl/GSM8452891_Pt-13A_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452891/suppl/GSM8452891_Pt-13A_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681369"
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452892",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8452892",
  "accession": "GSM8452892",
  "source_name": "Pt-13B",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Liver metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452892/suppl/GSM8452892_Pt-13_B.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452892/suppl/GSM8452892_Pt-13B_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452892/suppl/GSM8452892_Pt-13B_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "pei-2025:GSM8452893",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8452893",
  "accession": "GSM8452893",
  "source_name": "Pt-13C",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Lung metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452893/suppl/GSM8452893_Pt-13_C.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452893/suppl/GSM8452893_Pt-13C_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452893/suppl/GSM8452893_Pt-13C_spatial.tar.gz",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452894",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8452894",
  "accession": "GSM8452894",
  "source_name": "Pt-13D",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.306,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452894/suppl/GSM8452894_Pt-13_D.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452894/suppl/GSM8452894_Pt-13D_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452894/suppl/GSM8452894_Pt-13D_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681372"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8452895",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8452895",
  "accession": "GSM8452895",
  "source_name": "Pt-13E",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Peritoneal metastasis",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.307,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452895/suppl/GSM8452895_Pt-13_E.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452895/suppl/GSM8452895_Pt-13E_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8452nnn/GSM8452895/suppl/GSM8452895_Pt-13E_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX25681373"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8714177",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt3",
  "capture": "GSM8714177",
  "accession": "GSM8714177",
  "source_name": "Pt-3_Pri2",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Untreated",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: no treatment. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.303,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714177/suppl/GSM8714177_Pt-3_Pri2.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714177/suppl/GSM8714177_Pt3_Pri2_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714177/suppl/GSM8714177_Pt3_Pri2_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX27265158"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "89 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8714178",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt6",
  "capture": "GSM8714178",
  "accession": "GSM8714178",
  "source_name": "Pt-6_Pri2",
  "tier": "held",
  "tier_reason": "Original H&E about 0.68 µm/pixel versus about 0.31 for most Pei sections. Use if model scale is compatible; other Pt6 sections remain available.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, AVN944, erlotinib. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.676,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714178/suppl/GSM8714178_Pt-6_Pri2.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714178/suppl/GSM8714178_Pt6_Pri2_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714178/suppl/GSM8714178_Pt6_Pri2_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX27265159"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8714179",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt6",
  "capture": "GSM8714179",
  "accession": "GSM8714179",
  "source_name": "Pt-6_Pri3",
  "tier": "held",
  "tier_reason": "Original H&E about 0.68 µm/pixel versus about 0.31 for most Pei sections. Use if model scale is compatible; other Pt6 sections remain available.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: gemcitabine, AVN944, erlotinib. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.675,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714179/suppl/GSM8714179_Pt-6_Pri3.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714179/suppl/GSM8714179_Pt6_Pri3_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714179/suppl/GSM8714179_Pt6_Pri3_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX27265160"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "60 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8714180",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt8",
  "capture": "GSM8714180",
  "accession": "GSM8714180",
  "source_name": "Pt-8_Pri2",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, FOLFIRI, Abraxane/Gemcitabine. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.303,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714180/suppl/GSM8714180_Pt-8_Pri2.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714180/suppl/GSM8714180_Pt8_Pri2_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714180/suppl/GSM8714180_Pt8_Pri2_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX27265161"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "67 years (Table S1)",
   "sex": "M",
   "stage": "At diagnosis: IV; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8714181",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8714181",
  "accession": "GSM8714181",
  "source_name": "Pt-13_Pri2",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.303,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714181/suppl/GSM8714181_Pt-13_Pri2.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714181/suppl/GSM8714181_Pt13_Pri2_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714181/suppl/GSM8714181_Pt13_Pri2_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX27265162"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "pei-2025:GSM8714182",
  "cohort": "pei-2025",
  "cancer": "PDAC",
  "stratum": "pdac-conv",
  "patient": "Pt13",
  "capture": "GSM8714182",
  "accession": "GSM8714182",
  "source_name": "Pt-13_Pri3",
  "tier": "core",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Primary PDAC",
  "treatment": "Post-treatment",
  "treatment_note": "Clinical chemotherapy history before rapid-autopsy tissue collection: FOLFIRINOX, Capecitabine, gemcitabine/abraxane/ denosumab. Applies to this donor's sampled primary/metastatic sites.",
  "diagnosis": "Pancreatic ductal adenocarcinoma",
  "histology": "Pancreatic ductal adenocarcinoma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "same-section",
  "registration": "Original JPEG and spatial scaling match; full pixel-level QC pending",
  "he_mpp": 0.303,
  "he_mpp_basis": "From image header and scale factors",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714182/suppl/GSM8714182_Pt-13_Pri3.jpg.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714182/suppl/GSM8714182_Pt13_Pri3_filtered_feature_bc_matrix.h5",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8714nnn/GSM8714182/suppl/GSM8714182_Pt13_Pri3_spatial.tar.gz",
   "raw": [
    "https://www.ncbi.nlm.nih.gov/sra?term=SRX27265163"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "open"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "82 years (Table S1)",
   "sex": "F",
   "stage": "At diagnosis: III; at death: IV",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT224P1-S1Fc2U1Z1Bs1-1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_22",
  "capture": "HT224P1-S1Fc2U1Z1Bs1-1",
  "accession": "HTA12_22_4",
  "source_name": "HT224P1-S1Fc2U1Z1Bs1-1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Post-treatment",
  "treatment_note": "Published case treatment: FOLIRINOX, Gem/Abraxane. HTAN therapy: Yes; intent: Neoadjuvant; agents: Gemcitabine + Abrazane. Neoadjuvant therapy precedes the primary resection used for this case.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn51283209",
   "expression": "https://www.synapse.org/Synapse:syn51201492",
   "coordinates": "https://www.synapse.org/Synapse:syn51203271",
   "raw": [
    "https://www.synapse.org/Synapse:syn29282141",
    "https://www.synapse.org/Synapse:syn29290487",
    "https://www.synapse.org/Synapse:syn51201362"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "22239 days at diagnosis (source HTAN field)",
   "sex": "female",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT231P1-S1H3Fc2U1Z1Bs1-H3Bs2-Test",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_23",
  "capture": "HT231P1-S1H3Fc2U1Z1Bs1-H3Bs2-Test",
  "accession": "HTA12_23_3",
  "source_name": "HT231P1-S1H3Fc2U1Z1Bs1-H3Bs2-Test",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Post-treatment",
  "treatment_note": "Published case treatment: FOLFIRINOX, SBRT. HTAN therapy: Yes; intent: Neoadjuvant; agents: Folfirinox + guided SBRT. Neoadjuvant therapy precedes the primary resection used for this case.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn51283210",
   "expression": "https://www.synapse.org/Synapse:syn51201505",
   "coordinates": "https://www.synapse.org/Synapse:syn51203265",
   "raw": [
    "https://www.synapse.org/Synapse:syn29289888",
    "https://www.synapse.org/Synapse:syn29290431",
    "https://www.synapse.org/Synapse:syn51201393"
   ]
  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "22960 days at diagnosis (source HTAN field)",
   "sex": "female",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT242P1H1-S1Fc1U1Z1B1_1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_25",
  "capture": "HT242P1H1-S1Fc1U1Z1B1_1",
  "accession": "HTA12_25_5",
  "source_name": "HT242P1H1-S1Fc1U1Z1B1_1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: None. HTAN therapy: Yes; intent: not reported; agents: not reported. Published None conflicts with the therapy record; collection-relative timing must be reconciled.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
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  "histology": "Pancreatobiliary-type carcinoma",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465490",
   "expression": "https://www.synapse.org/Synapse:syn61462532",
   "coordinates": "https://www.synapse.org/Synapse:syn61462060",
   "raw": [
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    "https://www.synapse.org/Synapse:syn61465725"
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "22002 days at diagnosis (source HTAN field)",
   "sex": "male",
   "stage": "Stage IIB",
   "grade": "G2",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "htan-wustl:HT270P2-Fp1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_261",
  "capture": "HT270P2-Fp1U1Bp1",
  "accession": "HTA12_261_1",
  "source_name": "HT270P2-Fp1U1Bp1",
  "tier": "metastatic",
  "tier_reason": "Tumour-bearing metastasis; use as a secondary set with specimen site / treatment considered.",
  "site": "Metastasis",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: mFOLFIRINOX, 2. Adjuvant Peptide Vaccine trial (HRPO 201908124). HTAN therapy: yes; intent: Adjuvant; agents: mFOLFIRINOX. Treatment history is present or incomplete, but timing relative to the exact spatial specimen is unconfirmed.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465374",
   "expression": "https://www.synapse.org/Synapse:syn61462424",
   "coordinates": "https://www.synapse.org/Synapse:syn61462024",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "22003 days at diagnosis (source HTAN field)",
   "sex": "Male",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT416P1-S1H1A1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_264",
  "capture": "HT416P1-S1H1A1U1Bp1",
  "accession": "HTA12_264_2",
  "source_name": "HT416P1-S1H1A1U1Bp1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: None. HTAN therapy: yes; intent: Adjuvant; agents: Gemzar. Adjuvant therapy may follow a resection, but its relation to this exact spatial specimen is not established; no untreated assignment from intent alone.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465482",
   "expression": "https://www.synapse.org/Synapse:syn61462509",
   "coordinates": "https://www.synapse.org/Synapse:syn61462342",
   "raw": [
    "https://www.synapse.org/Synapse:syn61463545",
    "https://www.synapse.org/Synapse:syn61464722",
    "https://www.synapse.org/Synapse:syn61463971",
    "https://www.synapse.org/Synapse:syn61464047",
    "https://www.synapse.org/Synapse:syn61465251"
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "22468 days at diagnosis (source HTAN field)",
   "sex": "Female",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT424P1-H3A1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_265",
  "capture": "HT424P1-H3A1U1Bp1",
  "accession": "HTA12_265_1",
  "source_name": "HT424P1-H3A1U1Bp1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Post-treatment",
  "treatment_note": "Published case treatment: 4 cycles gem/abraxane. HTAN therapy: yes; intent: Neoadjuvant; agents: Gem/Abraxane. Neoadjuvant therapy precedes the primary resection used for this case.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465399",
   "expression": "https://www.synapse.org/Synapse:syn61462456",
   "coordinates": "https://www.synapse.org/Synapse:syn61462106",
   "raw": [
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    "https://www.synapse.org/Synapse:syn61463437",
    "https://www.synapse.org/Synapse:syn61464091",
    "https://www.synapse.org/Synapse:syn61463449",
    "https://www.synapse.org/Synapse:syn61465070"
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "27775 days at diagnosis (source HTAN field)",
   "sex": "Male",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT427P1-S1H1Fp1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_267",
  "capture": "HT427P1-S1H1Fp1U1Bp1",
  "accession": "HTA12_267_1",
  "source_name": "HT427P1-S1H1Fp1U1Bp1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Post-treatment",
  "treatment_note": "Published case treatment: FOLFIRINOX; reduced dose of Irinotecan. HTAN therapy: yes; intent: Neoadjuvant; agents: FOLFIRINOX. Neoadjuvant therapy precedes the primary resection used for this case.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465437",
   "expression": "https://www.synapse.org/Synapse:syn61462455",
   "coordinates": "https://www.synapse.org/Synapse:syn61462209",
   "raw": [
    "https://www.synapse.org/Synapse:syn61463671",
    "https://www.synapse.org/Synapse:syn61462882",
    "https://www.synapse.org/Synapse:syn61464025",
    "https://www.synapse.org/Synapse:syn61463939",
    "https://www.synapse.org/Synapse:syn61465103"
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
  },
  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "22302 days at diagnosis (source HTAN field)",
   "sex": "Female",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT434P1-S1H3Fp1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_268",
  "capture": "HT434P1-S1H3Fp1U1Bp1",
  "accession": "HTA12_268_2",
  "source_name": "HT434P1-S1H3Fp1U1Bp1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: None. HTAN therapy: yes; intent: Neoadjuvant; agents: CellDex Trial. Published None conflicts with the therapy record; collection-relative timing must be reconciled.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465387",
   "expression": "https://www.synapse.org/Synapse:syn61462465",
   "coordinates": "https://www.synapse.org/Synapse:syn61462015",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
   "raw": "controlled"
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  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "26217 days at diagnosis (source HTAN field)",
   "sex": "Female",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
 },
 {
  "id": "htan-wustl:HT553P1-S1H2Fp1U1Bp1",
  "cohort": "htan-wustl",
  "cancer": "PDAC",
  "stratum": "pdac-pb",
  "patient": "HTA12_273",
  "capture": "HT553P1-S1H2Fp1U1Bp1",
  "accession": "HTA12_273_2",
  "source_name": "HT553P1-S1H2Fp1U1Bp1",
  "tier": "review",
  "tier_reason": "Primary tumour candidate; remaining image and RNA QC still applies.",
  "site": "Primary",
  "site_source": "Not established at specimen level; see patient diagnostic site",
  "treatment": "Unknown",
  "treatment_note": "Published case treatment: None. HTAN therapy: yes; intent: Adjuvant; agents: FOLFIRINOX. Adjuvant therapy may follow a resection, but its relation to this exact spatial specimen is not established; no untreated assignment from intent alone.",
  "diagnosis": "Adenocarcinoma pancreatobiliary type",
  "histology": "Adenocarcinoma pancreatobiliary type",
  "technique": "Visium FFPE",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Original high-resolution TIFF, measured matrix, spot coordinates and scales listed together",
  "he_mpp": null,
  "he_mpp_basis": "20× objective per study methods; calibration not read",
  "he_file": null,
  "links": {
   "he": "https://www.synapse.org/Synapse:syn61465370",
   "expression": "https://www.synapse.org/Synapse:syn61462441",
   "coordinates": "https://www.synapse.org/Synapse:syn61462103",
   "raw": [
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  },
  "expression_type": null,
  "access": {
   "he": "account",
   "processed": "account",
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  "verification": "metadata-checked",
  "verified_on": "2026-10-09",
  "clinical": {
   "age": "25819 days at diagnosis (source HTAN field)",
   "sex": "Male",
   "stage": "Not reported",
   "grade": "Not reported",
   "subsite": null,
   "markers": "Not reported"
  },
  "image_level": "original"
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 {
  "id": "cand-yu2026atlas:GSM9519394",
  "cohort": "cand-yu2026atlas",
  "cancer": "BLCA",
  "stratum": null,
  "patient": null,
  "capture": "GSM9519394",
  "accession": "GSM9519394",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": "muscle-invasive bladder carcinoma",
  "histology": "muscle-invasive bladder carcinoma",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9519nnn/GSM9519394/suppl/GSM9519394_BC01_tissue_hires_image.png.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9519nnn/GSM9519394/suppl/GSM9519394_BC01_tissue_positions.csv.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "primary-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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  "field_sources": {
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   "site": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9519394"
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 {
  "id": "cand-yu2026atlas:GSM9519395",
  "cohort": "cand-yu2026atlas",
  "cancer": "BLCA",
  "stratum": null,
  "patient": null,
  "capture": "GSM9519395",
  "accession": "GSM9519395",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": "muscle-invasive bladder carcinoma",
  "histology": "muscle-invasive bladder carcinoma",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
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  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "primary-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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  "field_sources": {
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   "site": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9519395"
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 {
  "id": "cand-yu2026atlas:GSM9519396",
  "cohort": "cand-yu2026atlas",
  "cancer": "BLCA",
  "stratum": null,
  "patient": null,
  "capture": "GSM9519396",
  "accession": "GSM9519396",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
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  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
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  "histology": "muscle-invasive bladder carcinoma",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
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  "compartment": "primary-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-yu2026atlas:GSM9519397",
  "cohort": "cand-yu2026atlas",
  "cancer": "BLCA",
  "stratum": null,
  "patient": null,
  "capture": "GSM9519397",
  "accession": "GSM9519397",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
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  "histology": "muscle-invasive bladder carcinoma",
  "technique": "Visium CytAssist",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
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  "access": {
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
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  "donor_mapping": "unresolved",
  "open_checks": [
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   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9087nnn/GSM9087753/suppl/GSM9087753_CK17-159-2_matrix.mtx.gz",
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   "Response labels do not show that the sample was taken after immunotherapy; clinical timing and source site need confirmation."
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   "Eight PTC or locally advanced PTC sections and four normal sections; four ATC sections are kept separate. GEO records treatment as none."
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  "patient": null,
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  "patient": null,
  "capture": "GSM7980863",
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  "capture": "GSM7980865",
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  "he_mpp": null,
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  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7980nnn/GSM7980865/suppl/GSM7980865_PTC-2_visium_tissue_hires_image.png.gz",
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  "patient": null,
  "capture": "GSM7980866",
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  "diagnosis": null,
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  "links": {
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  "id": "cand-liao-2025-gse250521:GSM7980867",
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  "patient": null,
  "capture": "GSM7980867",
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  "tier": "review",
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  "diagnosis": null,
  "histology": null,
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  "links": {
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   "raw": []
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  "id": "cand-liao-2025-gse250521:GSM7980868",
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  "stratum": null,
  "patient": null,
  "capture": "GSM7980868",
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  "tier": "review",
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  "site_source": "tumour, exact site unconfirmed",
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  "diagnosis": null,
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  "links": {
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  "access": {
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  "stratum": null,
  "patient": null,
  "capture": "GSM7980869",
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  "tier": "review",
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  "site_source": "tumour, exact site unconfirmed",
  "treatment": "Unknown",
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  "histology": null,
  "technique": "Visium",
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  "links": {
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   "processed": "open",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903671",
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  "cancer": "CRC",
  "stratum": null,
  "patient": null,
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  "accession": "GSM8903671",
  "tier": "metastatic",
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  "site": "Metastasis",
  "site_source": "metastatic",
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  "he_mpp": null,
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   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903671/suppl/GSM8903671_M-ST-16.tar.gz",
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 {
  "id": "cand-gse238264:GSM7661261",
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  "stratum": null,
  "patient": "7",
  "capture": "GSM7661261",
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  "he_mpp": null,
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  "links": {
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661261/suppl/GSM7661261_HCC7NR.tar.gz",
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  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226208",
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  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-19",
  "capture": "GSM9226208",
  "accession": "GSM9226208",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
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  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226208/suppl/GSM9226208_P19_LUAD.tar.gz",
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  "id": "cand-peng-kadara-2025:GSM9226200",
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  "patient": "patient-15",
  "capture": "GSM9226200",
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  "registration": "Not yet checked",
  "he_mpp": null,
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  "id": "cand-peng-kadara-2025:GSM9226176",
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  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-4",
  "capture": "GSM9226176",
  "accession": "GSM9226176",
  "tier": "review",
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  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
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  "diagnosis": "AAH",
  "histology": "AAH",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226176/suppl/GSM9226176_P4_AAH-1.tar.gz",
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  "access": {
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   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903658",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903658",
  "accession": "GSM8903658",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
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  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903658/suppl/GSM8903658_IX_56689.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903658/suppl/GSM8903658_IX_56689.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903658/suppl/GSM8903658_IX_56689.tar.gz",
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  "access": {
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226220",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-24",
  "capture": "GSM9226220",
  "accession": "GSM9226220",
  "tier": "review",
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  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
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  "technique": "Visium CytAssist",
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  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226220/suppl/GSM9226220_P24_AAH.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226220/suppl/GSM9226220_P24_AAH.tar.gz",
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  "access": {
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   "raw": "unresolved"
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  "verified_on": "2026-10-16",
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  "compartment": "precursor",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903683",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903683",
  "accession": "GSM8903683",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903683/suppl/GSM8903683_M-ST-28.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903683/suppl/GSM8903683_M-ST-28.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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  "id": "cand-crc-liu-maru2026:GSM8903663",
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  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903663",
  "accession": "GSM8903663",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903663/suppl/GSM8903663_M-ST-08.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903663/suppl/GSM8903663_M-ST-08.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903663/suppl/GSM8903663_M-ST-08.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
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  "clinical": {},
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-crc-liu-maru2026:GSM8903677",
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  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903677",
  "accession": "GSM8903677",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
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   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903677/suppl/GSM8903677_M-ST-22.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903677/suppl/GSM8903677_M-ST-22.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
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  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226180",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-6",
  "capture": "GSM9226180",
  "accession": "GSM9226180",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226180/suppl/GSM9226180_P6_AAH.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226180/suppl/GSM9226180_P6_AAH.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226180/suppl/GSM9226180_P6_AAH.tar.gz",
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  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "donor_mapping": "source-sample-title",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226199",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-15",
  "capture": "GSM9226199",
  "accession": "GSM9226199",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "MIA",
  "histology": "MIA",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226199/suppl/GSM9226199_P15_MIA.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226199/suppl/GSM9226199_P15_MIA.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226199/suppl/GSM9226199_P15_MIA.tar.gz",
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  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903691",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903691",
  "accession": "GSM8903691",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903691/suppl/GSM8903691_M-ST-36.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903691/suppl/GSM8903691_M-ST-36.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903691/suppl/GSM8903691_M-ST-36.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
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 {
  "id": "cand-peng-kadara-2025:GSM9226216",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-22",
  "capture": "GSM9226216",
  "accession": "GSM9226216",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226216/suppl/GSM9226216_P22_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226216/suppl/GSM9226216_P22_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226216/suppl/GSM9226216_P22_LUAD.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226216",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226214",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-22",
  "capture": "GSM9226214",
  "accession": "GSM9226214",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226214/suppl/GSM9226214_P22_AAH.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226214/suppl/GSM9226214_P22_AAH.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226214/suppl/GSM9226214_P22_AAH.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903667",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903667",
  "accession": "GSM8903667",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903667/suppl/GSM8903667_M-ST-12.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903667/suppl/GSM8903667_M-ST-12.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903667/suppl/GSM8903667_M-ST-12.tar.gz",
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  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226191",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-11",
  "capture": "GSM9226191",
  "accession": "GSM9226191",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226191/suppl/GSM9226191_P11_AAH.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226191/suppl/GSM9226191_P11_AAH.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226191/suppl/GSM9226191_P11_AAH.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "donor_mapping": "source-sample-title",
  "open_checks": [
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  "field_sources": {
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226191",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226211",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-21",
  "capture": "GSM9226211",
  "accession": "GSM9226211",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226211/suppl/GSM9226211_P21_AIS.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226211/suppl/GSM9226211_P21_AIS.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226211/suppl/GSM9226211_P21_AIS.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226207",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-19",
  "capture": "GSM9226207",
  "accession": "GSM9226207",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226207/suppl/GSM9226207_P19_AIS.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226207/suppl/GSM9226207_P19_AIS.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226207/suppl/GSM9226207_P19_AIS.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "precursor",
  "donor_mapping": "source-sample-title",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226182",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-7",
  "capture": "GSM9226182",
  "accession": "GSM9226182",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
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  "id": "cand-peng-kadara-2025:GSM9226177",
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  "he_mpp": null,
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  "links": {
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  "id": "cand-peng-kadara-2025:GSM9226217",
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  "patient": "patient-23",
  "capture": "GSM9226217",
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  "treatment": "Untreated",
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  "registration": "Not yet checked",
  "he_mpp": null,
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  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226217/suppl/GSM9226217_P23_AIS.tar.gz",
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  "id": "cand-peng-kadara-2025:GSM9226189",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-10",
  "capture": "GSM9226189",
  "accession": "GSM9226189",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
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  "site_source": "primary tumour",
  "treatment": "Untreated",
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  "diagnosis": "MIA",
  "histology": "MIA",
  "technique": "Visium CytAssist",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226189/suppl/GSM9226189_P10_MIA.tar.gz",
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  "id": "cand-peng-kadara-2025:GSM9226201",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-16",
  "capture": "GSM9226201",
  "accession": "GSM9226201",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
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  "technique": "Visium CytAssist",
  "preservation": "FFPE",
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  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226201/suppl/GSM9226201_P16_AIS.tar.gz",
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 {
  "id": "cand-peng-kadara-2025:GSM9226169",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-1",
  "capture": "GSM9226169",
  "accession": "GSM9226169",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226169/suppl/GSM9226169_P1_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226169/suppl/GSM9226169_P1_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226169/suppl/GSM9226169_P1_LUAD.tar.gz",
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  "access": {
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-he2024:GSM8340239",
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  "patient": null,
  "capture": "GSM8340239",
  "accession": "GSM8340239",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
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  "preservation": "Fresh frozen",
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  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340239/suppl/GSM8340239_HG2.png.gz",
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  },
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   "processed": "open",
   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
  "clinical": {
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   "Provenance and geometry of the RAW PNG files, donor, histology, grade and overlap with reused data remain to be checked."
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 {
  "id": "cand-crc-liu-maru2026:GSM8903661",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903661",
  "accession": "GSM8903661",
  "tier": "metastatic",
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  "site": "Metastasis",
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  "treatment": "Unknown",
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  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903661/suppl/GSM8903661_M-ST-06.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903661/suppl/GSM8903661_M-ST-06.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903661/suppl/GSM8903661_M-ST-06.tar.gz",
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  "access": {
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226218",
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  "cancer": "LUAD",
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  "patient": "patient-23",
  "capture": "GSM9226218",
  "accession": "GSM9226218",
  "tier": "review",
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  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
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  "histology": "AIS",
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  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226218/suppl/GSM9226218_P23_AIS-1.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "raw": "unresolved"
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  "verified_on": "2026-10-16",
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  "donor_mapping": "source-sample-title",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903675",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903675",
  "accession": "GSM8903675",
  "tier": "metastatic",
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  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903675/suppl/GSM8903675_M-ST-20.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903675/suppl/GSM8903675_M-ST-20.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903675/suppl/GSM8903675_M-ST-20.tar.gz",
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   "processed": "open",
   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-he2024:GSM8340238",
  "cohort": "cand-he2024",
  "cancer": "LGG",
  "stratum": null,
  "patient": null,
  "capture": "GSM8340238",
  "accession": "GSM8340238",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": "High-Grade Glioma",
  "histology": "High-Grade Glioma",
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  "preservation": "Fresh frozen",
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  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340238/suppl/GSM8340238_HG1.png.gz",
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   "processed": "open",
   "raw": "unresolved"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903693",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903693",
  "accession": "GSM8903693",
  "tier": "metastatic",
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  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903693/suppl/GSM8903693_M-ST-38.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903693/suppl/GSM8903693_M-ST-38.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903693/suppl/GSM8903693_M-ST-38.tar.gz",
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   "processed": "open",
   "raw": "unresolved"
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  "open_checks": [
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 {
  "id": "cand-crc-liu-maru2026:GSM8903669",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903669",
  "accession": "GSM8903669",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903669/suppl/GSM8903669_M-ST-14.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903669/suppl/GSM8903669_M-ST-14.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903669/suppl/GSM8903669_M-ST-14.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
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  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226171",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-2",
  "capture": "GSM9226171",
  "accession": "GSM9226171",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226171/suppl/GSM9226171_P2_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226171/suppl/GSM9226171_P2_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226171/suppl/GSM9226171_P2_LUAD.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-gse238264:GSM7661259",
  "cohort": "cand-gse238264",
  "cancer": "LIHC",
  "stratum": null,
  "patient": "5",
  "capture": "GSM7661259",
  "accession": "GSM7661259",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Post-treatment",
  "treatment_note": "cabozantinib+nivolumab, source-reported treated",
  "diagnosis": null,
  "histology": null,
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661259/suppl/GSM7661259_HCC5NR.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661259/suppl/GSM7661259_HCC5NR.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661259/suppl/GSM7661259_HCC5NR.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
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  "verified_on": "2026-10-16",
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  "image_level": "preview",
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  "compartment": null,
  "donor_mapping": "source-established",
  "open_checks": [
   "The source reports treatment with cabozantinib and nivolumab."
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 {
  "id": "cand-peng-kadara-2025:GSM9226204",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-17",
  "capture": "GSM9226204",
  "accession": "GSM9226204",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226204/suppl/GSM9226204_P17_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226204/suppl/GSM9226204_P17_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226204/suppl/GSM9226204_P17_LUAD.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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  "field_sources": {
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226204",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-gse238264:GSM7661255",
  "cohort": "cand-gse238264",
  "cancer": "LIHC",
  "stratum": null,
  "patient": "1",
  "capture": "GSM7661255",
  "accession": "GSM7661255",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Post-treatment",
  "treatment_note": "cabozantinib+nivolumab, source-reported treated",
  "diagnosis": null,
  "histology": null,
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661255/suppl/GSM7661255_HCC1R.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661255/suppl/GSM7661255_HCC1R.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661255/suppl/GSM7661255_HCC1R.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": null,
  "donor_mapping": "source-established",
  "open_checks": [
   "The source reports treatment with cabozantinib and nivolumab."
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226184",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-8",
  "capture": "GSM9226184",
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  "site": "Unknown",
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  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
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  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
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 {
  "id": "cand-peng-kadara-2025:GSM9226209",
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  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-20",
  "capture": "GSM9226209",
  "accession": "GSM9226209",
  "tier": "review",
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  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226209/suppl/GSM9226209_P20_AAH.tar.gz",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903665",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903665",
  "accession": "GSM8903665",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903665/suppl/GSM8903665_M-ST-10.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903665/suppl/GSM8903665_M-ST-10.tar.gz",
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  "access": {
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   "processed": "open",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226172",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-3",
  "capture": "GSM9226172",
  "accession": "GSM9226172",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226172/suppl/GSM9226172_P3_AIS.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226172/suppl/GSM9226172_P3_AIS.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226172/suppl/GSM9226172_P3_AIS.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
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  "verified_on": "2026-10-16",
  "clinical": {},
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903679",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903679",
  "accession": "GSM8903679",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
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  "histology": null,
  "technique": "Visium HD",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903679/suppl/GSM8903679_M-ST-24.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903679/suppl/GSM8903679_M-ST-24.tar.gz",
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  "access": {
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   "raw": "unresolved"
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  "compartment": "metastatic-tumour",
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  "open_checks": [
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 {
  "id": "cand-he2024:GSM8340236",
  "cohort": "cand-he2024",
  "cancer": "LGG",
  "stratum": null,
  "patient": null,
  "capture": "GSM8340236",
  "accession": "GSM8340236",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
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  "histology": "Low-Grade Glioma",
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  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340236/suppl/GSM8340236_LG1.png.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340236/suppl/GSM8340236_LG1.png.gz",
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  "access": {
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   "raw": "unresolved"
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {
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  "compartment": null,
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  "id": "cand-peng-kadara-2025:GSM9226185",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-8",
  "capture": "GSM9226185",
  "accession": "GSM9226185",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
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  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226185/suppl/GSM9226185_P8_LUAD.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226185/suppl/GSM9226185_P8_LUAD.tar.gz",
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  "verified_on": "2026-10-16",
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  "compartment": "primary-tumour",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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  "id": "cand-he2024:GSM8340237",
  "cohort": "cand-he2024",
  "cancer": "LGG",
  "stratum": null,
  "patient": null,
  "capture": "GSM8340237",
  "accession": "GSM8340237",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Unknown",
  "treatment_note": null,
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  "histology": "Low-Grade Glioma",
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340237/suppl/GSM8340237_LG2.png.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340237/suppl/GSM8340237_LG2.png.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8340nnn/GSM8340237/suppl/GSM8340237_LG2.png.gz",
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  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {
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  "image_level": "preview",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903685",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903685",
  "accession": "GSM8903685",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903685/suppl/GSM8903685_M-ST-30.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903685/suppl/GSM8903685_M-ST-30.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903685/suppl/GSM8903685_M-ST-30.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226198",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-14",
  "capture": "GSM9226198",
  "accession": "GSM9226198",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226198/suppl/GSM9226198_P14_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226198/suppl/GSM9226198_P14_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226198/suppl/GSM9226198_P14_LUAD.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903676",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903676",
  "accession": "GSM8903676",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903676/suppl/GSM8903676_M-ST-21.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903676/suppl/GSM8903676_M-ST-21.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903676/suppl/GSM8903676_M-ST-21.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
  ]
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 {
  "id": "cand-peng-kadara-2025:GSM9226219",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-23",
  "capture": "GSM9226219",
  "accession": "GSM9226219",
  "tier": "review",
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  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226219/suppl/GSM9226219_P23_LUAD.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226219/suppl/GSM9226219_P23_LUAD.tar.gz",
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  "verified_on": "2026-10-16",
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 {
  "id": "cand-peng-kadara-2025:GSM9226194",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-12",
  "capture": "GSM9226194",
  "accession": "GSM9226194",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
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  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226194/suppl/GSM9226194_P12_LUAD.tar.gz",
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  "access": {
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  "verified_on": "2026-10-16",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903662",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903662",
  "accession": "GSM8903662",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903662/suppl/GSM8903662_M-ST-07.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903662/suppl/GSM8903662_M-ST-07.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903662/suppl/GSM8903662_M-ST-07.tar.gz",
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  "access": {
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   "processed": "open",
   "raw": "unresolved"
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  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903684",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903684",
  "accession": "GSM8903684",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903684/suppl/GSM8903684_M-ST-29.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903684/suppl/GSM8903684_M-ST-29.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903684/suppl/GSM8903684_M-ST-29.tar.gz",
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  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
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 {
  "id": "cand-peng-kadara-2025:GSM9226221",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-24",
  "capture": "GSM9226221",
  "accession": "GSM9226221",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226221/suppl/GSM9226221_P24_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226221/suppl/GSM9226221_P24_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226221/suppl/GSM9226221_P24_LUAD.tar.gz",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903690",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903690",
  "accession": "GSM8903690",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
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  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903690/suppl/GSM8903690_M-ST-35.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903690/suppl/GSM8903690_M-ST-35.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903690/suppl/GSM8903690_M-ST-35.tar.gz",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903657",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903657",
  "accession": "GSM8903657",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
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  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
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  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903657/suppl/GSM8903657_IX_56688.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903657/suppl/GSM8903657_IX_56688.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903657/suppl/GSM8903657_IX_56688.tar.gz",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903678",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903678",
  "accession": "GSM8903678",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903678/suppl/GSM8903678_M-ST-23.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903678/suppl/GSM8903678_M-ST-23.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903678/suppl/GSM8903678_M-ST-23.tar.gz",
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  "access": {
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  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226195",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-13",
  "capture": "GSM9226195",
  "accession": "GSM9226195",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "MIA",
  "histology": "MIA",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226195/suppl/GSM9226195_P13_MIA.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226195/suppl/GSM9226195_P13_MIA.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226195/suppl/GSM9226195_P13_MIA.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
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  "donor_mapping": "source-sample-title",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903670",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903670",
  "accession": "GSM8903670",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903670/suppl/GSM8903670_M-ST-15.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903670/suppl/GSM8903670_M-ST-15.tar.gz",
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  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226173",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-3",
  "capture": "GSM9226173",
  "accession": "GSM9226173",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226173/suppl/GSM9226173_P3_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226173/suppl/GSM9226173_P3_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226173/suppl/GSM9226173_P3_LUAD.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
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  "verification": "file-checked",
  "verified_on": "2026-10-16",
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  "image_level": "preview",
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  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226215",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-22",
  "capture": "GSM9226215",
  "accession": "GSM9226215",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
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 {
  "id": "cand-peng-kadara-2025:GSM9226170",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-2",
  "capture": "GSM9226170",
  "accession": "GSM9226170",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226170/suppl/GSM9226170_P2_AAH.tar.gz",
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  "access": {
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 {
  "id": "cand-peng-kadara-2025:GSM9226203",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-17",
  "capture": "GSM9226203",
  "accession": "GSM9226203",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226203/suppl/GSM9226203_P17_AIS.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226203/suppl/GSM9226203_P17_AIS.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226203/suppl/GSM9226203_P17_AIS.tar.gz",
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  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "donor_mapping": "source-sample-title",
  "open_checks": [
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 {
  "id": "cand-crc-liu-maru2026:GSM8903664",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903664",
  "accession": "GSM8903664",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903664/suppl/GSM8903664_M-ST-09.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903664/suppl/GSM8903664_M-ST-09.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903664/suppl/GSM8903664_M-ST-09.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226186",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-9",
  "capture": "GSM9226186",
  "accession": "GSM9226186",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
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  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226186/suppl/GSM9226186_P9_AAH.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226186/suppl/GSM9226186_P9_AAH.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226186/suppl/GSM9226186_P9_AAH.tar.gz",
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  "access": {
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   "processed": "open",
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  "verified_on": "2026-10-16",
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  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-crc-liu-maru2026:GSM8903682",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903682",
  "accession": "GSM8903682",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903682/suppl/GSM8903682_M-ST-27.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903682/suppl/GSM8903682_M-ST-27.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903682/suppl/GSM8903682_M-ST-27.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 {
  "id": "cand-crc-liu-maru2026:GSM8903668",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903668",
  "accession": "GSM8903668",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903668/suppl/GSM8903668_M-ST-13.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903668/suppl/GSM8903668_M-ST-13.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "raw": "unresolved"
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  "verified_on": "2026-10-16",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 },
 {
  "id": "cand-peng-kadara-2025:GSM9226188",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-9",
  "capture": "GSM9226188",
  "accession": "GSM9226188",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226188/suppl/GSM9226188_P9_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226188/suppl/GSM9226188_P9_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226188/suppl/GSM9226188_P9_LUAD.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "primary-tumour",
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  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226192",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-11",
  "capture": "GSM9226192",
  "accession": "GSM9226192",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226192/suppl/GSM9226192_P11_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226192/suppl/GSM9226192_P11_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226192/suppl/GSM9226192_P11_LUAD.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226192",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226179",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-5",
  "capture": "GSM9226179",
  "accession": "GSM9226179",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226179/suppl/GSM9226179_P5_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226179/suppl/GSM9226179_P5_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226179/suppl/GSM9226179_P5_LUAD.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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  "field_sources": {
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226179",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
  }
 },
 {
  "id": "cand-peng-kadara-2025:GSM9226175",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-4",
  "capture": "GSM9226175",
  "accession": "GSM9226175",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226175/suppl/GSM9226175_P4_AAH.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226175/suppl/GSM9226175_P4_AAH.tar.gz",
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  "id": "cand-crc-liu-maru2026:GSM8903659",
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  "histology": null,
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  "he_mpp": null,
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  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903659/suppl/GSM8903659_IX_56690.tar.gz",
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  "open_checks": [
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 {
  "id": "cand-crc-liu-maru2026:GSM8903686",
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  "cancer": "CRC",
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  "patient": null,
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  "site": "Metastasis",
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  "technique": "Visium HD",
  "preservation": "FFPE",
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  "he_mpp": null,
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903686/suppl/GSM8903686_M-ST-31.tar.gz",
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 {
  "id": "cand-peng-kadara-2025:GSM9226213",
  "cohort": "cand-peng-kadara-2025",
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  "patient": "patient-21",
  "capture": "GSM9226213",
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  "registration": "Not yet checked",
  "he_mpp": null,
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  "id": "cand-crc-liu-maru2026:GSM8903666",
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  "cancer": "CRC",
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  "patient": null,
  "capture": "GSM8903666",
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  "tier": "metastatic",
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  "he_mpp": null,
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  "he_file": null,
  "links": {
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 {
  "id": "cand-crc-liu-maru2026:GSM8903688",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903688",
  "accession": "GSM8903688",
  "tier": "metastatic",
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  "site": "Metastasis",
  "site_source": "metastatic",
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  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903688/suppl/GSM8903688_M-ST-33.tar.gz",
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   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903688/suppl/GSM8903688_M-ST-33.tar.gz",
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  "open_checks": [
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 {
  "id": "cand-peng-kadara-2025:GSM9226210",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-20",
  "capture": "GSM9226210",
  "accession": "GSM9226210",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
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  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226210/suppl/GSM9226210_P20_LUAD.tar.gz",
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  "compartment": "primary-tumour",
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226202",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-16",
  "capture": "GSM9226202",
  "accession": "GSM9226202",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226202/suppl/GSM9226202_P16_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226202/suppl/GSM9226202_P16_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226202/suppl/GSM9226202_P16_LUAD.tar.gz",
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  "access": {
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 {
  "id": "cand-peng-kadara-2025:GSM9226197",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-14",
  "capture": "GSM9226197",
  "accession": "GSM9226197",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226197/suppl/GSM9226197_P14_AIS.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226197/suppl/GSM9226197_P14_AIS.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226197/suppl/GSM9226197_P14_AIS.tar.gz",
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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  "verified_on": "2026-10-16",
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 {
  "id": "cand-crc-liu-maru2026:GSM8903660",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903660",
  "accession": "GSM8903660",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903660/suppl/GSM8903660_M-ST-05.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903660/suppl/GSM8903660_M-ST-05.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903660/suppl/GSM8903660_M-ST-05.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 },
 {
  "id": "cand-gse238264:GSM7661256",
  "cohort": "cand-gse238264",
  "cancer": "LIHC",
  "stratum": null,
  "patient": "2",
  "capture": "GSM7661256",
  "accession": "GSM7661256",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Post-treatment",
  "treatment_note": "cabozantinib+nivolumab, source-reported treated",
  "diagnosis": null,
  "histology": null,
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661256/suppl/GSM7661256_HCC2R.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661256/suppl/GSM7661256_HCC2R.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661256/suppl/GSM7661256_HCC2R.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": null,
  "donor_mapping": "source-established",
  "open_checks": [
   "The source reports treatment with cabozantinib and nivolumab."
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 {
  "id": "cand-peng-kadara-2025:GSM9226178",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-5",
  "capture": "GSM9226178",
  "accession": "GSM9226178",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AIS",
  "histology": "AIS",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226178/suppl/GSM9226178_P5_AIS.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226178/suppl/GSM9226178_P5_AIS.tar.gz",
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 {
  "id": "cand-peng-kadara-2025:GSM9226174",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-4",
  "capture": "GSM9226174",
  "accession": "GSM9226174",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "normal",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "normal",
  "histology": "normal",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226174/suppl/GSM9226174_P4_Normal.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226174/suppl/GSM9226174_P4_Normal.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226174/suppl/GSM9226174_P4_Normal.tar.gz",
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  },
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  "access": {
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   "processed": "open",
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  },
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  "verified_on": "2026-10-16",
  "clinical": {},
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 {
  "id": "cand-crc-liu-maru2026:GSM8903692",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903692",
  "accession": "GSM8903692",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903692/suppl/GSM8903692_M-ST-37.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903692/suppl/GSM8903692_M-ST-37.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903692/suppl/GSM8903692_M-ST-37.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
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 },
 {
  "id": "cand-crc-liu-maru2026:GSM8903674",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903674",
  "accession": "GSM8903674",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903674/suppl/GSM8903674_M-ST-19.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903674/suppl/GSM8903674_M-ST-19.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903674/suppl/GSM8903674_M-ST-19.tar.gz",
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  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
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  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
  ]
 },
 {
  "id": "cand-peng-kadara-2025:GSM9226206",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-18",
  "capture": "GSM9226206",
  "accession": "GSM9226206",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226206/suppl/GSM9226206_P18_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226206/suppl/GSM9226206_P18_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226206/suppl/GSM9226206_P18_LUAD.tar.gz",
   "raw": []
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  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
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  "verified_on": "2026-10-16",
  "clinical": {},
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  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226205",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-18",
  "capture": "GSM9226205",
  "accession": "GSM9226205",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "MIA",
  "histology": "MIA",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226205/suppl/GSM9226205_P18_MIA.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226205/suppl/GSM9226205_P18_MIA.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226205/suppl/GSM9226205_P18_MIA.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
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   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
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  "donor_mapping": "source-sample-title",
  "open_checks": [
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   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226181",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-6",
  "capture": "GSM9226181",
  "accession": "GSM9226181",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226181/suppl/GSM9226181_P6_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226181/suppl/GSM9226181_P6_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226181/suppl/GSM9226181_P6_LUAD.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
   "Only the 30 invasive or minimally invasive sections are tumour; precursor and normal sections stay separate, and a patient's repeated sections stay linked."
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  "field_sources": {
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226181",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
  }
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 {
  "id": "cand-crc-liu-maru2026:GSM8903672",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903672",
  "accession": "GSM8903672",
  "tier": "metastatic",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Metastasis",
  "site_source": "metastatic",
  "treatment": "Unknown",
  "treatment_note": null,
  "diagnosis": null,
  "histology": null,
  "technique": "Visium HD",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903672/suppl/GSM8903672_M-ST-17.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903672/suppl/GSM8903672_M-ST-17.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM8903nnn/GSM8903672/suppl/GSM8903672_M-ST-17.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "metastatic-tumour",
  "donor_mapping": "unresolved",
  "open_checks": [
   "All 37 deposited tissues are colorectal metastases; the donor count is unknown and treatment unresolved."
  ]
 },
 {
  "id": "cand-peng-kadara-2025:GSM9226190",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-10",
  "capture": "GSM9226190",
  "accession": "GSM9226190",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Primary",
  "site_source": "primary tumour",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "LUAD",
  "histology": "LUAD",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226190/suppl/GSM9226190_P10_LUAD.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226190/suppl/GSM9226190_P10_LUAD.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226190/suppl/GSM9226190_P10_LUAD.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "primary-tumour",
  "donor_mapping": "source-sample-title",
  "open_checks": [
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  "field_sources": {
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226190",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
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 {
  "id": "cand-peng-kadara-2025:GSM9226222",
  "cohort": "cand-peng-kadara-2025",
  "cancer": "LUAD",
  "stratum": null,
  "patient": "patient-25",
  "capture": "GSM9226222",
  "accession": "GSM9226222",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": "precursor",
  "treatment": "Untreated",
  "treatment_note": "Treatment-naive (study-level statement in the GEO series)",
  "diagnosis": "AAH",
  "histology": "AAH",
  "technique": "Visium CytAssist",
  "preservation": "FFPE",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226222/suppl/GSM9226222_P25_AAH.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226222/suppl/GSM9226222_P25_AAH.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226222/suppl/GSM9226222_P25_AAH.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": "precursor",
  "donor_mapping": "source-sample-title",
  "open_checks": [
   "Only the 30 invasive or minimally invasive sections are tumour; precursor and normal sections stay separate, and a patient's repeated sections stay linked."
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  "field_sources": {
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   "donor_mapping": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSM9226222",
   "treatment": "https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE307534"
  }
 },
 {
  "id": "cand-gse238264:GSM7661257",
  "cohort": "cand-gse238264",
  "cancer": "LIHC",
  "stratum": null,
  "patient": "3",
  "capture": "GSM7661257",
  "accession": "GSM7661257",
  "tier": "review",
  "tier_reason": "Matched data with preview image; the original H&E was not located. Not curated into a histology stratum.",
  "site": "Unknown",
  "site_source": null,
  "treatment": "Post-treatment",
  "treatment_note": "cabozantinib+nivolumab, source-reported treated",
  "diagnosis": null,
  "histology": null,
  "technique": "Visium",
  "preservation": "Fresh frozen",
  "linkage": "listed-together",
  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661257/suppl/GSM7661257_HCC3R.tar.gz",
   "expression": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661257/suppl/GSM7661257_HCC3R.tar.gz",
   "coordinates": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM7661nnn/GSM7661257/suppl/GSM7661257_HCC3R.tar.gz",
   "raw": []
  },
  "expression_type": "Expression barcodes match the tissue coordinates exactly",
  "access": {
   "he": "open",
   "processed": "open",
   "raw": "unresolved"
  },
  "verification": "file-checked",
  "verified_on": "2026-10-16",
  "clinical": {},
  "image_level": "preview",
  "review_batch": "backlog-2026-10-16",
  "compartment": null,
  "donor_mapping": "source-established",
  "open_checks": [
   "The source reports treatment with cabozantinib and nivolumab."
  ]
 },
 {
  "id": "cand-crc-liu-maru2026:GSM8903680",
  "cohort": "cand-crc-liu-maru2026",
  "cancer": "CRC",
  "stratum": null,
  "patient": null,
  "capture": "GSM8903680",
  "accession": "GSM8903680",
  "tier": "metastatic",
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  "id": "cand-gse238264:GSM7661258",
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  "patient": "patient-7",
  "capture": "GSM9226183",
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  "he_mpp": null,
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  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226183/suppl/GSM9226183_P7_LUAD-1.tar.gz",
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  "patient": "patient-21",
  "capture": "GSM9226212",
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  "links": {
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  "patient": "patient-1",
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  "registration": "Not yet checked",
  "he_mpp": null,
  "he_mpp_basis": "Scanner calibration pending",
  "he_file": null,
  "links": {
   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226168/suppl/GSM9226168_P1_AAH.tar.gz",
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  "id": "cand-peng-kadara-2025:GSM9226196",
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  "stratum": null,
  "patient": "patient-13",
  "capture": "GSM9226196",
  "accession": "GSM9226196",
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   "he": "https://ftp.ncbi.nlm.nih.gov/geo/samples/GSM9226nnn/GSM9226196/suppl/GSM9226196_P13_LUAD.tar.gz",
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  "capture": "GSM9226223",
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  "he_mpp": null,
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  "he_file": null,
  "links": {
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  "id": "cand-peng-kadara-2025:GSM9226187",
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  "stratum": null,
  "patient": "patient-9",
  "capture": "GSM9226187",
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  "links": {
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  "stratum": null,
  "patient": "1160920F",
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